Gut Immune Maturation Depends on Colonization with a Host-Specific Microbiota

Hachung Chung, Sünje Johanna Pamp, Jonathan A. Hill, Neeraj K. Surana, Sanna M. Edelman, Erin B. Troy, Nicola C. Reading, Eduardo J. Villablanca, Sen Wang, Jorge R. Mora, Yoshinori Umesaki, Diane Mathis, Christophe Benoist, David A. Relman, Dennis L. Kasper

Research output: Contribution to journalJournal articleResearchpeer-review


Germ-free mice that lack intestinal microbiota are immunodeficient, with failed maturation of gut immune cells. Inoculation of these mice with either human or rat microbiota does not support gut immunity either, suggesting that mammalian hosts have coevolved with a specific consortium of bacterial species that stimulates intestinal immune maturation.
Original languageEnglish
Issue number7
Pages (from-to)1578-1593
Publication statusPublished - 2012
Externally publishedYes


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