Guiding recombinant antivenom development by omics technologies

Andreas Hougaard Laustsen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Abstract

In this review, the different approaches that have been employed with the aim of developing novel antivenoms against animal envenomings are presented and discussed. Reported efforts have focused on the use of innovative immunization strategies, small molecule inhibitors against enzymatic toxins, endogenous animal proteins with toxin-neutralizing capabilities, and recombinant monoclonal antibodies. Harnessing either of these approaches, antivenom development may benefit from an in-depth understanding of venom compositions and the medical importance of individual venom toxins. Focus is thus also directed towards the different omics technologies (particularly venomics, antivenomics, and toxicovenomics) that are being used to uncover novel animal toxins, shed light on venom complexity, and provide directions for how to determine the medical relevance of individual toxins within whole venoms. Finally, techniques for assessing antivenom specificity and cross-reactivity are reviewed, with special focus on antivenomics and high-density peptide microarray technology.
Original languageEnglish
JournalNew Biotechnology
Volume45
Pages (from-to)19-27
ISSN1871-6784
DOIs
Publication statusPublished - 2018

Keywords

  • Animal envenomings
  • Antivenomics
  • High-density peptide microarray technology
  • Omics technologies
  • Recombinant antivenom
  • Snakebite
  • Toxicovenomics
  • Venomics

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