This Special Issue includes selected papers from the 2nd NorCAS conference held in Copenhagen, Denmark, November 2016. The NorCAS conference is the result of a merger between the former International Symposium on Systems-on-Chip and the Norchip conference which has been held annually since 1983. A Special Issue from this conference has been published by Springer (initially Kluwer) since the Norchip 1992 conference in Helsinki, so this issue covering the 2016 NorCAS conference marks the 25th anniversary of Norchip/NorCAS Special Issues. The conference covers all fields of electronics, spanning from complex digital systems to advanced analog and mixed-mode circuits. For this Special Issue, the papers are selected among those dealing with analog and mixed-mode circuits and systems. More than 25 papers were presented in this field, and from these, 8 papers have been selected for the Special Issue, covering topics in energy harvesting, data conversion, voltage regulators and sensor interfaces. Hopefully, you will find interesting reading in some of these papers.