Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

Li Xu, Yanli Wen, Santosh Pandit, Venkata R. S. S. Mokkapati, Ivan Mijakovic*, Yan Li, Min Ding, Shuzhen Ren, Wen Li, Gang Liu

*Corresponding author for this work

Research output: Contribution to journalReviewResearchpeer-review

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Abstract

Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.
Original languageEnglish
Article number112
JournalBMC Chemistry
Volume13
ISSN2661-801X
DOIs
Publication statusPublished - 2019

Cite this

Xu, Li ; Wen, Yanli ; Pandit, Santosh ; Mokkapati, Venkata R. S. S. ; Mijakovic, Ivan ; Li, Yan ; Ding, Min ; Ren, Shuzhen ; Li, Wen ; Liu, Gang. / Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review. In: BMC Chemistry. 2019 ; Vol. 13.
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title = "Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review",
abstract = "Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10{\%} of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.",
author = "Li Xu and Yanli Wen and Santosh Pandit and Mokkapati, {Venkata R. S. S.} and Ivan Mijakovic and Yan Li and Min Ding and Shuzhen Ren and Wen Li and Gang Liu",
year = "2019",
doi = "10.1186/s13065-019-0611-x",
language = "English",
volume = "13",
journal = "BMC Chemistry",
issn = "2661-801X",

}

Xu, L, Wen, Y, Pandit, S, Mokkapati, VRSS, Mijakovic, I, Li, Y, Ding, M, Ren, S, Li, W & Liu, G 2019, 'Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review', BMC Chemistry, vol. 13, 112. https://doi.org/10.1186/s13065-019-0611-x

Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review. / Xu, Li; Wen, Yanli; Pandit, Santosh; Mokkapati, Venkata R. S. S.; Mijakovic, Ivan; Li, Yan; Ding, Min; Ren, Shuzhen; Li, Wen; Liu, Gang.

In: BMC Chemistry, Vol. 13, 112, 2019.

Research output: Contribution to journalReviewResearchpeer-review

TY - JOUR

T1 - Graphene-based biosensors for the detection of prostate cancer protein biomarkers: a review

AU - Xu, Li

AU - Wen, Yanli

AU - Pandit, Santosh

AU - Mokkapati, Venkata R. S. S.

AU - Mijakovic, Ivan

AU - Li, Yan

AU - Ding, Min

AU - Ren, Shuzhen

AU - Li, Wen

AU - Liu, Gang

PY - 2019

Y1 - 2019

N2 - Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.

AB - Prostate cancer (PC) is the sixth most common cancer type in the world, which causes approximately 10% of total cancer fatalities. The detection of protein biomarkers in body fluids is the key topic for the diagnosis and prognosis of PC. Highly sensitive screening of PC is the most effective approach for reducing mortality. Thus, there are a growing number of literature that recognizes the importance of new technologies for early diagnosis of PC. Graphene is playing an important role in the biosensor field with remarkable physical, optical, electrochemical and magnetic properties. Many recent studies demonstrated the potential of graphene materials for sensitive detection of protein biomarkers. In this review, the graphene-based biosensors toward PC analysis are mainly discussed in two groups: Firstly, novel biosensor interfaces were constructed through the modification of graphene materials onto sensor surfaces. Secondly, ingenious signal amplification strategies were developed using graphene materials as catalysts or carriers. Graphene-based biosensors have exhibited remarkable performance with high sensitivities, wide detection ranges, and long-term stabilities.

U2 - 10.1186/s13065-019-0611-x

DO - 10.1186/s13065-019-0611-x

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VL - 13

JO - BMC Chemistry

JF - BMC Chemistry

SN - 2661-801X

M1 - 112

ER -