Graph-Based Methods for Discovery Browsing with Semantic Predications

Bartlomiej Wilkowski, Marcelo Fiszman, Christopher M Miller, Dimitar Hristovski, Sivaram Arabandi, Graciela Rosemblat, Thomas C Rindflesch

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    Abstract

    We present an extension to literature-based discovery that goes beyond making discoveries to a principled way of navigating through selected aspects of some biomedical domain. The method is a type of "discovery browsing" that guides the user through the research literature on a specified phenomenon. Poorly understood relationships may be explored through novel points of view, and potentially interesting relationships need not be known ahead of time. In a process of "cooperative reciprocity" the user iteratively focuses system output, thus controlling the large number of relationships often generated in literature-based discovery systems. The underlying technology exploits SemRep semantic predications represented as a graph of interconnected nodes (predication arguments) and edges (predicates). The system suggests paths in this graph, which represent chains of relationships. The methodology is illustrated with depressive disorder and focuses on the interaction of inflammation, circadian phenomena, and the neurotransmitter norepinephrine. Insight provided may contribute to enhanced understanding of the pathophysiology, treatment, and prevention of this disorder.
    Original languageEnglish
    JournalA A M I Annual Meeting. Proceedings
    Volume2011
    Pages (from-to)1514-1523
    ISSN0146-146X
    Publication statusPublished - 2011
    EventAMIA Annual Symposium - Wasington, USA
    Duration: 1 Jan 2011 → …

    Conference

    ConferenceAMIA Annual Symposium
    CityWasington, USA
    Period01/01/2011 → …

    Bibliographical note

    This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose.

    Cite this

    Wilkowski, B., Fiszman, M., Miller, C. M., Hristovski, D., Arabandi, S., Rosemblat, G., & Rindflesch, T. C. (2011). Graph-Based Methods for Discovery Browsing with Semantic Predications. A A M I Annual Meeting. Proceedings, 2011, 1514-1523. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243228/