GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

Ole Raaschou-Nielsen; Mette Sørensen; Rikke D. Hansen; Kirsten Frederiksen; Anne Tjønneland; Kim Overvad; Ulla Birgitte Vogel

doi:10.1016/j.canlet.2006.05.006

GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

Ole Raaschou-Nielsen, Mette Sørensen, Rikke D. Hansen, Kirsten Frederiksen, Anne Tjønneland, Kim Overvad, Ulla Birgitte Vogel

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Journal	Cancer Letters
Volume	247
Issue number	2
Pages (from-to)	293-300
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.canlet.2006.05.006
Publication status	Published - 2007
Externally published	Yes

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title = "GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer",

abstract = "We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.",

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doi = "10.1016/j.canlet.2006.05.006",

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T1 - GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

AU - Raaschou-Nielsen, Ole

AU - Sørensen, Mette

AU - Hansen, Rikke D.

AU - Frederiksen, Kirsten

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Vogel, Ulla Birgitte

PY - 2007

Y1 - 2007

N2 - We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

AB - We genotyped blood samples from 432 lung cancer cases and 798 persons in a comparison group and examined the role of the GPX1 (Pro198Leu, rs1050450) polymorphism and interactions with external exposures in the development of lung cancer. The incidence rate ratio for lung cancer was 0.60 (95% confidence interval: 0.35-1.05) when homozygous carriers of the variant allele were compared with the homozygous carriers of the wild type, and the risk for lung cancer was significantly lower among participants carrying more variant alleles (p-trend = 0.03). We found stronger associations between several smoking variables and alcohol intake and lung cancer risk among GPX1(TT) carriers than among GPX1(CC) and GPX1(CT) carriers. (c) 2006 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.canlet.2006.05.006

DO - 10.1016/j.canlet.2006.05.006

M3 - Journal article

SN - 0304-3835

VL - 247

SP - 293

EP - 300

JO - Cancer Letters

JF - Cancer Letters

IS - 2

ER -

GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer

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