Glycosylation of proteins

Bjørn Voldborg (Inventor), Stefan Kol (Inventor), Anders Hansen (Inventor), Helene Kildegaard (Inventor)

Research output: Patent

89 Downloads (Pure)

Abstract

The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.

Original languageEnglish
IPCC12P 21/ 02 A I
Patent numberWO2019105770
Filing date28/11/2017
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date11/07/2018
Priority numberEP20180182948
Publication statusPublished - 6 Jun 2019

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