Glycosylation of proteins

Bjørn Voldborg (Inventor), Stefan Kol (Inventor), Anders Hansen (Inventor), Helene Kildegaard (Inventor)

Research output: Patent

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Abstract

The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.

Original languageEnglish
IPCC12P 21/ 02 A I
Patent numberWO2019105770
Filing date28/11/2017
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date11/07/2018
Priority numberEP20180182948
Publication statusPublished - 6 Jun 2019

Cite this

Voldborg, B., Kol, S., Hansen, A., & Kildegaard, H. (2019). IPC No. C12P 21/ 02 A I. Glycosylation of proteins. (Patent No. WO2019105770).
Voldborg, Bjørn (Inventor) ; Kol, Stefan (Inventor) ; Hansen, Anders (Inventor) ; Kildegaard, Helene (Inventor). / Glycosylation of proteins. IPC No.: C12P 21/ 02 A I. Patent No.: WO2019105770. Nov 28, 2017.
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Voldborg, B, Kol, S, Hansen, A & Kildegaard, H Nov. 28 2017, Glycosylation of proteins, Patent No. WO2019105770, IPC No. C12P 21/ 02 A I.

Glycosylation of proteins. / Voldborg, Bjørn (Inventor); Kol, Stefan (Inventor); Hansen, Anders (Inventor); Kildegaard, Helene (Inventor).

IPC No.: C12P 21/ 02 A I. Patent No.: WO2019105770. Nov 28, 2017.

Research output: Patent

TY - PAT

T1 - Glycosylation of proteins

AU - Voldborg, Bjørn

AU - Kol, Stefan

AU - Hansen, Anders

AU - Kildegaard, Helene

PY - 2019/6/6

Y1 - 2019/6/6

N2 - The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.

AB - The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.

M3 - Patent

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Y2 - 2017/11/28

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Voldborg B, Kol S, Hansen A, Kildegaard H, inventors. Glycosylation of proteins. C12P 21/ 02 A I. 2019 Jun 6.