Abstract
The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced serum glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.
| Original language | English |
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| IPC | C12P 21/ 02 A I |
| Patent number | WO2019105770 |
| Filing date | 28/11/2017 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 11/07/2018 |
| Priority number | EP20180182948 |
| Publication status | Published - 6 Jun 2019 |