Glycerol–Silicone Membranes for Sustained and Controlled Topical Delivery of Antimicrobial and Pain‐Relief Drugs

Piotr Mazurek, Nikoline S. Frederiksen, Harald Silau, Nuura A. Yuusuf, Hanne Mordhorst, Sünje J. Pamp, Anne L. Skov*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Controlling drug delivery from medical dressings to wounds remains a challenge despite the presence of multiple drug-containing wound dressings on the market. The dressing should ideally be effective immediately after application and still show no burst effect, and must also be comfortable for an extended period of time. Here, a silicone-based membrane is shown to offer an adjustable, constant release of various drugs even at a minimum moisture level resembling that of dry wounds. The drugs are dissolved in glycerol, which is speed-mixed with silicone and subsequently cured to yield a solid membrane with evenly distributed glycerol microcontainers housing the drug. The drugs are released immediately upon contact with moisture, enabling efficient treatment with short response time and no burst. Drug delivery capability is evaluated using a classical drug release experiment, as well as by performing an antimicrobial susceptibility test on ten bacterial strains in agar diffusion assays. Results show that glycerol–silicone membranes are promising candidates for fighting bacterial infections. Moreover, the addition of glycerol domains to a silicone matrix is proven to have a positive impact on water vapor transmission rate and moisture handling capabilities, resulting in a more skin compliant dressing.
Original languageEnglish
Article number2001873
JournalAdvanced Materials Interfaces
Volume8
Issue number5
Number of pages11
ISSN2196-7350
DOIs
Publication statusPublished - 2021

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