Glycerol-silicone elastomer as active matrices with controllable release profiles

P. Mazurek*, M. A. Brook, A. L. Skov

*Corresponding author for this work

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

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Abstract

Drug release regimes must be controlled for optimal therapeutic effect. While it is relatively straightforward to create first order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases, but are even more difficult to formulate. We describe the straightforward synthesis of elastomeric composites prepared from silicone in which the active is dispersed in glycerol. The release of glycerol-soluble actives from films of these materials was shown to be tunable with respect to the order of release (zero- or first-order) simply by changing glycerol content. Importantly, release from the elastomers showed no burst effect. The discrete glycerol domains embedded within a silicone matrix act as reservoirs for active substances. Upon contact with aqueous media the active substances are released from matrices exhibiting zero-order, near zero-order or first-order release kinetics. Various parameters that could influence the release process include glycerol content, glycerol domain size or membrane thickness are thoroughly investigated, elucidating guidelines for creating matrices capable of delivering active substances at desired rates. Additionally, the composites proved to absorb significant amounts of liquid water (up to 1850 % of sample mass), a feature that can be tuned by manipulation of the composite structure.
Original languageEnglish
Publication date2019
Number of pages1
Publication statusPublished - 2019
Event83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019 - Prague, Czech Republic
Duration: 23 Jun 201927 Jun 2019

Conference

Conference83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019
CountryCzech Republic
CityPrague
Period23/06/201927/06/2019

Cite this

Mazurek, P., Brook, M. A., & Skov, A. L. (2019). Glycerol-silicone elastomer as active matrices with controllable release profiles. Abstract from 83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019, Prague, Czech Republic.
Mazurek, P. ; Brook, M. A. ; Skov, A. L. / Glycerol-silicone elastomer as active matrices with controllable release profiles. Abstract from 83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019, Prague, Czech Republic.1 p.
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abstract = "Drug release regimes must be controlled for optimal therapeutic effect. While it is relatively straightforward to create first order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases, but are even more difficult to formulate. We describe the straightforward synthesis of elastomeric composites prepared from silicone in which the active is dispersed in glycerol. The release of glycerol-soluble actives from films of these materials was shown to be tunable with respect to the order of release (zero- or first-order) simply by changing glycerol content. Importantly, release from the elastomers showed no burst effect. The discrete glycerol domains embedded within a silicone matrix act as reservoirs for active substances. Upon contact with aqueous media the active substances are released from matrices exhibiting zero-order, near zero-order or first-order release kinetics. Various parameters that could influence the release process include glycerol content, glycerol domain size or membrane thickness are thoroughly investigated, elucidating guidelines for creating matrices capable of delivering active substances at desired rates. Additionally, the composites proved to absorb significant amounts of liquid water (up to 1850 {\%} of sample mass), a feature that can be tuned by manipulation of the composite structure.",
author = "P. Mazurek and Brook, {M. A.} and Skov, {A. L.}",
year = "2019",
language = "English",
note = "83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019 ; Conference date: 23-06-2019 Through 27-06-2019",

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Mazurek, P, Brook, MA & Skov, AL 2019, 'Glycerol-silicone elastomer as active matrices with controllable release profiles', 83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019, Prague, Czech Republic, 23/06/2019 - 27/06/2019.

Glycerol-silicone elastomer as active matrices with controllable release profiles. / Mazurek, P.; Brook, M. A. ; Skov, A. L.

2019. Abstract from 83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019, Prague, Czech Republic.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

TY - ABST

T1 - Glycerol-silicone elastomer as active matrices with controllable release profiles

AU - Mazurek, P.

AU - Brook, M. A.

AU - Skov, A. L.

PY - 2019

Y1 - 2019

N2 - Drug release regimes must be controlled for optimal therapeutic effect. While it is relatively straightforward to create first order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases, but are even more difficult to formulate. We describe the straightforward synthesis of elastomeric composites prepared from silicone in which the active is dispersed in glycerol. The release of glycerol-soluble actives from films of these materials was shown to be tunable with respect to the order of release (zero- or first-order) simply by changing glycerol content. Importantly, release from the elastomers showed no burst effect. The discrete glycerol domains embedded within a silicone matrix act as reservoirs for active substances. Upon contact with aqueous media the active substances are released from matrices exhibiting zero-order, near zero-order or first-order release kinetics. Various parameters that could influence the release process include glycerol content, glycerol domain size or membrane thickness are thoroughly investigated, elucidating guidelines for creating matrices capable of delivering active substances at desired rates. Additionally, the composites proved to absorb significant amounts of liquid water (up to 1850 % of sample mass), a feature that can be tuned by manipulation of the composite structure.

AB - Drug release regimes must be controlled for optimal therapeutic effect. While it is relatively straightforward to create first order release matrices, it can be challenging to avoid an initial burst. Matrices with zero-order profiles are perceived to be beneficial in many cases, but are even more difficult to formulate. We describe the straightforward synthesis of elastomeric composites prepared from silicone in which the active is dispersed in glycerol. The release of glycerol-soluble actives from films of these materials was shown to be tunable with respect to the order of release (zero- or first-order) simply by changing glycerol content. Importantly, release from the elastomers showed no burst effect. The discrete glycerol domains embedded within a silicone matrix act as reservoirs for active substances. Upon contact with aqueous media the active substances are released from matrices exhibiting zero-order, near zero-order or first-order release kinetics. Various parameters that could influence the release process include glycerol content, glycerol domain size or membrane thickness are thoroughly investigated, elucidating guidelines for creating matrices capable of delivering active substances at desired rates. Additionally, the composites proved to absorb significant amounts of liquid water (up to 1850 % of sample mass), a feature that can be tuned by manipulation of the composite structure.

M3 - Conference abstract for conference

ER -

Mazurek P, Brook MA, Skov AL. Glycerol-silicone elastomer as active matrices with controllable release profiles. 2019. Abstract from 83rd Prague Meeting on Macromolecules – Polymers in Medicine 2019, Prague, Czech Republic.