Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts

Sydney K. Willis*, Lauren A. Wise, Amelia K. Wesselink, Kenneth J. Rothman, Ellen M. Mikkelsen, Katherine L. Tucker, Ellen Trolle, Elizabeth E. Hatch

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Glycemic load (GL) reflects the quantity and quality of carbohydrates in the diet; dietary fiber and added sugar are components of GL. Few epidemiologic studies have assessed the association between these dietary factors and fecundability. We prospectively evaluated the associations of GL, total carbohydrates, dietary fiber, and added sugar with fecundability. Snart Foraeldre (SF) and Pregnancy Study Online (PRESTO) are parallel web-based prospective preconception cohorts of couples attempting to conceive in Denmark and North America. At baseline, female participants completed a web-based questionnaire on demographic and lifestyle factors and a validated FFQ. We calculated GL, total carbohydrate intake, total dietary fiber, carbohydrate-to-fiber ratio, and added sugar based on reported frequencies for individual foods, standard recipes for mixed foods, and average serving sizes. The analysis included 2709 SF participants and 4268 PRESTO participants. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95% CIs. Compared with an average daily GL of ≤100, FRs for an average daily GL of ≥141 were 0.89 (95% CI: 0.73, 1.08) in SF and 0.87 (95% CI: 0.77, 0.98) in PRESTO participants. Compared with consuming ≤16 g/d of dietary fiber, FRs for consuming ≥25 g/d were 0.99 (95% CI: 0.81, 1.22) in SF and 1.06 (95% CI: 0.94, 1.20) in PRESTO. Compared with a carbohydrate-to-fiber ratio of ≤8, FRs for a ratio of ≥13 were 0.86 (95% CI: 0.73, 1.01) in SF and 0.87 (95% CI: 0.78, 0.98) in PRESTO. Compared with ≤27 g/d of added sugar, FRs for ≥72 g/d were 0.87 (95% CI: 0.68, 1.10) in SF and 0.86 (95% CI: 0.75, 0.99) in PRESTO participants. Among women attempting to conceive in Denmark and North America, diets high in GL, carbohydrate-to-fiber ratio, and added sugar were associated with modestly reduced fecundability.
Original languageEnglish
JournalAmerican Journal of Clinical Nutrition
Number of pages12
ISSN0002-9165
DOIs
Publication statusAccepted/In press - 2020

Cite this

Willis, S. K., Wise, L. A., Wesselink, A. K., Rothman, K. J., Mikkelsen, E. M., Tucker, K. L., ... Hatch, E. E. (Accepted/In press). Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts. American Journal of Clinical Nutrition. https://doi.org/10.1093/ajcn/nqz312
Willis, Sydney K. ; Wise, Lauren A. ; Wesselink, Amelia K. ; Rothman, Kenneth J. ; Mikkelsen, Ellen M. ; Tucker, Katherine L. ; Trolle, Ellen ; Hatch, Elizabeth E. / Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts. In: American Journal of Clinical Nutrition. 2020.
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title = "Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts",
abstract = "Glycemic load (GL) reflects the quantity and quality of carbohydrates in the diet; dietary fiber and added sugar are components of GL. Few epidemiologic studies have assessed the association between these dietary factors and fecundability. We prospectively evaluated the associations of GL, total carbohydrates, dietary fiber, and added sugar with fecundability. Snart Foraeldre (SF) and Pregnancy Study Online (PRESTO) are parallel web-based prospective preconception cohorts of couples attempting to conceive in Denmark and North America. At baseline, female participants completed a web-based questionnaire on demographic and lifestyle factors and a validated FFQ. We calculated GL, total carbohydrate intake, total dietary fiber, carbohydrate-to-fiber ratio, and added sugar based on reported frequencies for individual foods, standard recipes for mixed foods, and average serving sizes. The analysis included 2709 SF participants and 4268 PRESTO participants. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95{\%} CIs. Compared with an average daily GL of ≤100, FRs for an average daily GL of ≥141 were 0.89 (95{\%} CI: 0.73, 1.08) in SF and 0.87 (95{\%} CI: 0.77, 0.98) in PRESTO participants. Compared with consuming ≤16 g/d of dietary fiber, FRs for consuming ≥25 g/d were 0.99 (95{\%} CI: 0.81, 1.22) in SF and 1.06 (95{\%} CI: 0.94, 1.20) in PRESTO. Compared with a carbohydrate-to-fiber ratio of ≤8, FRs for a ratio of ≥13 were 0.86 (95{\%} CI: 0.73, 1.01) in SF and 0.87 (95{\%} CI: 0.78, 0.98) in PRESTO. Compared with ≤27 g/d of added sugar, FRs for ≥72 g/d were 0.87 (95{\%} CI: 0.68, 1.10) in SF and 0.86 (95{\%} CI: 0.75, 0.99) in PRESTO participants. Among women attempting to conceive in Denmark and North America, diets high in GL, carbohydrate-to-fiber ratio, and added sugar were associated with modestly reduced fecundability.",
author = "Willis, {Sydney K.} and Wise, {Lauren A.} and Wesselink, {Amelia K.} and Rothman, {Kenneth J.} and Mikkelsen, {Ellen M.} and Tucker, {Katherine L.} and Ellen Trolle and Hatch, {Elizabeth E.}",
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Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts. / Willis, Sydney K.; Wise, Lauren A.; Wesselink, Amelia K.; Rothman, Kenneth J.; Mikkelsen, Ellen M.; Tucker, Katherine L.; Trolle, Ellen; Hatch, Elizabeth E.

In: American Journal of Clinical Nutrition, 2020.

Research output: Contribution to journalJournal articleResearchpeer-review

TY - JOUR

T1 - Glycemic load, dietary fiber, and added sugar and fecundability in 2 preconception cohorts

AU - Willis, Sydney K.

AU - Wise, Lauren A.

AU - Wesselink, Amelia K.

AU - Rothman, Kenneth J.

AU - Mikkelsen, Ellen M.

AU - Tucker, Katherine L.

AU - Trolle, Ellen

AU - Hatch, Elizabeth E.

PY - 2020

Y1 - 2020

N2 - Glycemic load (GL) reflects the quantity and quality of carbohydrates in the diet; dietary fiber and added sugar are components of GL. Few epidemiologic studies have assessed the association between these dietary factors and fecundability. We prospectively evaluated the associations of GL, total carbohydrates, dietary fiber, and added sugar with fecundability. Snart Foraeldre (SF) and Pregnancy Study Online (PRESTO) are parallel web-based prospective preconception cohorts of couples attempting to conceive in Denmark and North America. At baseline, female participants completed a web-based questionnaire on demographic and lifestyle factors and a validated FFQ. We calculated GL, total carbohydrate intake, total dietary fiber, carbohydrate-to-fiber ratio, and added sugar based on reported frequencies for individual foods, standard recipes for mixed foods, and average serving sizes. The analysis included 2709 SF participants and 4268 PRESTO participants. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95% CIs. Compared with an average daily GL of ≤100, FRs for an average daily GL of ≥141 were 0.89 (95% CI: 0.73, 1.08) in SF and 0.87 (95% CI: 0.77, 0.98) in PRESTO participants. Compared with consuming ≤16 g/d of dietary fiber, FRs for consuming ≥25 g/d were 0.99 (95% CI: 0.81, 1.22) in SF and 1.06 (95% CI: 0.94, 1.20) in PRESTO. Compared with a carbohydrate-to-fiber ratio of ≤8, FRs for a ratio of ≥13 were 0.86 (95% CI: 0.73, 1.01) in SF and 0.87 (95% CI: 0.78, 0.98) in PRESTO. Compared with ≤27 g/d of added sugar, FRs for ≥72 g/d were 0.87 (95% CI: 0.68, 1.10) in SF and 0.86 (95% CI: 0.75, 0.99) in PRESTO participants. Among women attempting to conceive in Denmark and North America, diets high in GL, carbohydrate-to-fiber ratio, and added sugar were associated with modestly reduced fecundability.

AB - Glycemic load (GL) reflects the quantity and quality of carbohydrates in the diet; dietary fiber and added sugar are components of GL. Few epidemiologic studies have assessed the association between these dietary factors and fecundability. We prospectively evaluated the associations of GL, total carbohydrates, dietary fiber, and added sugar with fecundability. Snart Foraeldre (SF) and Pregnancy Study Online (PRESTO) are parallel web-based prospective preconception cohorts of couples attempting to conceive in Denmark and North America. At baseline, female participants completed a web-based questionnaire on demographic and lifestyle factors and a validated FFQ. We calculated GL, total carbohydrate intake, total dietary fiber, carbohydrate-to-fiber ratio, and added sugar based on reported frequencies for individual foods, standard recipes for mixed foods, and average serving sizes. The analysis included 2709 SF participants and 4268 PRESTO participants. We used proportional probabilities regression models to estimate fecundability ratios (FR) and 95% CIs. Compared with an average daily GL of ≤100, FRs for an average daily GL of ≥141 were 0.89 (95% CI: 0.73, 1.08) in SF and 0.87 (95% CI: 0.77, 0.98) in PRESTO participants. Compared with consuming ≤16 g/d of dietary fiber, FRs for consuming ≥25 g/d were 0.99 (95% CI: 0.81, 1.22) in SF and 1.06 (95% CI: 0.94, 1.20) in PRESTO. Compared with a carbohydrate-to-fiber ratio of ≤8, FRs for a ratio of ≥13 were 0.86 (95% CI: 0.73, 1.01) in SF and 0.87 (95% CI: 0.78, 0.98) in PRESTO. Compared with ≤27 g/d of added sugar, FRs for ≥72 g/d were 0.87 (95% CI: 0.68, 1.10) in SF and 0.86 (95% CI: 0.75, 0.99) in PRESTO participants. Among women attempting to conceive in Denmark and North America, diets high in GL, carbohydrate-to-fiber ratio, and added sugar were associated with modestly reduced fecundability.

U2 - 10.1093/ajcn/nqz312

DO - 10.1093/ajcn/nqz312

M3 - Journal article

C2 - 31901163

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

ER -