Glucose repression in Saccharomyces cerevisiae

Omur Kayikci, Jens Nielsen

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Abstract

Glucose is the primary source of energy for the budding yeast Saccharomyces cerevisiae. Although yeast cells can utilize a wide range of carbon sources, presence of glucose suppresses molecular activities involved in the use of alternate carbon sources as well as it represses respiration and gluconeogenesis. This dominant effect of glucose on yeast carbon metabolism is coordinated by several signaling and metabolic interactions that mainly regulate transcriptional activity but are also effective at post-transcriptional and post-translational levels. This review describes effects of glucose repression on yeast carbon metabolism with a focus on roles of the Snf3/Rgt2 glucose-sensing pathway and Snf1 signal transduction in establishment and relief of glucose repression.
Original languageEnglish
Article numberfov068
JournalFEMS Yeast Research
Volume15
Issue number5
Number of pages8
ISSN1567-1356
DOIs
Publication statusPublished - 2015

Keywords

  • Carbon metabolism
  • Snf1 signaling
  • Carbon catabolite repression

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