Giant Glial Cell: New Insight Through Mechanism-Based Modeling

D. E. Postnov, L. S. Ryazanova, Nadezda Brazhe, Alexey Brazhe, G.V. Maximov, Erik Mosekilde, Olga Sosnovtseva

Research output: Contribution to journalConference articleResearchpeer-review


The paper describes a detailed mechanism-based model of a tripartite synapse consisting of P- and R-neurons together with a giant glial cell in the ganglia of the medical leech (Hirudo medicinalis), which is a useful object for experimental studies in situ. We describe the two main pathways of the glial cell activation: (1) via IP3 production and Ca2+ release from the endoplasmic reticulum and (2) via increase of the extracellular potassium concentration, glia depolarization, and opening of voltage-dependent Ca2+ channels. We suggest that the second pathway is the more significant for establishing the positive feedback in glutamate release that is critical for the self-sustained activity of the postsynaptic neuron. This mechanism differs from the mechanisms of the astrocyte-neuron signaling previously reported.
Original languageEnglish
JournalJournal of Biological Physics
Issue number3-4
Pages (from-to)441-457
Publication statusPublished - 2008


  • Glia
  • Tripartite synapse
  • Modeling
  • Neuron

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