Geometrical optimization of microstripe arrays for microbead magnetophoresis

Anders Dahl Henriksen, Noemi Rozlosnik, Mikkel Fougt Hansen

    Research output: Contribution to journalJournal articleResearchpeer-review

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    Abstract

    Manipulation of magnetic beads plays an increasingly important role in molecular diagnostics. Magnetophoresis is a promising technique for selective transportation of magnetic beads in lab-on-a-chip systems. We investigate periodic arrays of exchange-biased permalloy microstripes fabricated using a single lithography step. Magnetic beads can be continuously moved across such arrays by combining the spatially periodic magnetic field from microstripes with a rotating external magnetic field. By measuring and modeling the magnetophoresis properties of thirteen different stripe designs, we study the effect of the stripe geometry on the magnetophoretic transport properties of the magnetic microbeads between the stripes. We show that a symmetric geometry with equal width of and spacing between the microstripes facilitates faster transportation and that the optimal period of the periodic stripe array is approximately three times the height of the bead center over the microstripes.
    Original languageEnglish
    Article number054123
    JournalBiomicrofluidics
    Volume9
    Issue number5
    Number of pages14
    ISSN1932-1058
    DOIs
    Publication statusPublished - 2015

    Bibliographical note

    © 2015 AIP Publishing LLC

    Cite this

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    title = "Geometrical optimization of microstripe arrays for microbead magnetophoresis",
    abstract = "Manipulation of magnetic beads plays an increasingly important role in molecular diagnostics. Magnetophoresis is a promising technique for selective transportation of magnetic beads in lab-on-a-chip systems. We investigate periodic arrays of exchange-biased permalloy microstripes fabricated using a single lithography step. Magnetic beads can be continuously moved across such arrays by combining the spatially periodic magnetic field from microstripes with a rotating external magnetic field. By measuring and modeling the magnetophoresis properties of thirteen different stripe designs, we study the effect of the stripe geometry on the magnetophoretic transport properties of the magnetic microbeads between the stripes. We show that a symmetric geometry with equal width of and spacing between the microstripes facilitates faster transportation and that the optimal period of the periodic stripe array is approximately three times the height of the bead center over the microstripes.",
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    Geometrical optimization of microstripe arrays for microbead magnetophoresis. / Henriksen, Anders Dahl; Rozlosnik, Noemi; Hansen, Mikkel Fougt.

    In: Biomicrofluidics, Vol. 9, No. 5, 054123, 2015.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Geometrical optimization of microstripe arrays for microbead magnetophoresis

    AU - Henriksen, Anders Dahl

    AU - Rozlosnik, Noemi

    AU - Hansen, Mikkel Fougt

    N1 - © 2015 AIP Publishing LLC

    PY - 2015

    Y1 - 2015

    N2 - Manipulation of magnetic beads plays an increasingly important role in molecular diagnostics. Magnetophoresis is a promising technique for selective transportation of magnetic beads in lab-on-a-chip systems. We investigate periodic arrays of exchange-biased permalloy microstripes fabricated using a single lithography step. Magnetic beads can be continuously moved across such arrays by combining the spatially periodic magnetic field from microstripes with a rotating external magnetic field. By measuring and modeling the magnetophoresis properties of thirteen different stripe designs, we study the effect of the stripe geometry on the magnetophoretic transport properties of the magnetic microbeads between the stripes. We show that a symmetric geometry with equal width of and spacing between the microstripes facilitates faster transportation and that the optimal period of the periodic stripe array is approximately three times the height of the bead center over the microstripes.

    AB - Manipulation of magnetic beads plays an increasingly important role in molecular diagnostics. Magnetophoresis is a promising technique for selective transportation of magnetic beads in lab-on-a-chip systems. We investigate periodic arrays of exchange-biased permalloy microstripes fabricated using a single lithography step. Magnetic beads can be continuously moved across such arrays by combining the spatially periodic magnetic field from microstripes with a rotating external magnetic field. By measuring and modeling the magnetophoresis properties of thirteen different stripe designs, we study the effect of the stripe geometry on the magnetophoretic transport properties of the magnetic microbeads between the stripes. We show that a symmetric geometry with equal width of and spacing between the microstripes facilitates faster transportation and that the optimal period of the periodic stripe array is approximately three times the height of the bead center over the microstripes.

    U2 - 10.1063/1.4934679

    DO - 10.1063/1.4934679

    M3 - Journal article

    VL - 9

    JO - Biomicrofluidics

    JF - Biomicrofluidics

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