Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015

S. L. Smits; S. D. Pas; C. B. Reusken; B. L. Haagmans; P. Pertile; C. Cancedda; K. Dierberg; I. Wurie; A. Kamara; D. Kargbo; S. L. Caddy; Armando Arias; L. Thorne; J. Lu; U. Jah; I. Goodfellow; M. P. Koopmans

doi:10.2807/1560-7917.ES.2015.20.40.30035

Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015

S. L. Smits, S. D. Pas, C. B. Reusken, B. L. Haagmans, P. Pertile, C. Cancedda, K. Dierberg, I. Wurie, A. Kamara, D. Kargbo, S. L. Caddy, Armando Arias, L. Thorne, J. Lu, U. Jah, I. Goodfellow, M. P. Koopmans

University of Cambridge

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapienswt/ SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.

Original language	English
Journal	Eurosurveillance (Online Edition)
Volume	20
Issue number	40
Number of pages	5
ISSN	1025-496X
DOIs	https://doi.org/10.2807/1560-7917.ES.2015.20.40.30035
Publication status	Published - 2015
Externally published	Yes

Keywords

Epidemiology
Public Health, Environmental and Occupational Health
Virology
Africa
Article
Ebola hemorrhagic fever
Ebolavirus
evolution
genetic variability
genome analysis
haplotype
human
mutation
nonhuman
nucleotide sequence
sequence alignment
Sierra Leone
virus genome
virus strain
Ebola virus
surveillance
viral infections

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.2807/1560-7917.ES.2015.20.40.30035

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Smits, S. L., Pas, S. D., Reusken, C. B., Haagmans, B. L., Pertile, P., Cancedda, C., Dierberg, K., Wurie, I., Kamara, A., Kargbo, D., Caddy, S. L., Arias, A., Thorne, L., Lu, J., Jah, U., Goodfellow, I., & Koopmans, M. P. (2015). Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015. Eurosurveillance (Online Edition), 20(40). https://doi.org/10.2807/1560-7917.ES.2015.20.40.30035

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abstract = "The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapienswt/ SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.",

keywords = "Epidemiology, Public Health, Environmental and Occupational Health, Virology, Africa, Article, Ebola hemorrhagic fever, Ebolavirus, evolution, genetic variability, genome analysis, haplotype, human, mutation, nonhuman, nucleotide sequence, sequence alignment, Sierra Leone, virus genome, virus strain, Ebola virus, surveillance, viral infections",

author = "Smits, {S. L.} and Pas, {S. D.} and Reusken, {C. B.} and Haagmans, {B. L.} and P. Pertile and C. Cancedda and K. Dierberg and I. Wurie and A. Kamara and D. Kargbo and Caddy, {S. L.} and Armando Arias and L. Thorne and J. Lu and U. Jah and I. Goodfellow and Koopmans, {M. P.}",

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doi = "10.2807/1560-7917.ES.2015.20.40.30035",

language = "English",

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Smits, SL, Pas, SD, Reusken, CB, Haagmans, BL, Pertile, P, Cancedda, C, Dierberg, K, Wurie, I, Kamara, A, Kargbo, D, Caddy, SL, Arias, A, Thorne, L, Lu, J, Jah, U, Goodfellow, I & Koopmans, MP 2015, 'Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015', Eurosurveillance (Online Edition), vol. 20, no. 40. https://doi.org/10.2807/1560-7917.ES.2015.20.40.30035

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T1 - Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015

AU - Smits, S. L.

AU - Pas, S. D.

AU - Reusken, C. B.

AU - Haagmans, B. L.

AU - Pertile, P.

AU - Cancedda, C.

AU - Dierberg, K.

AU - Wurie, I.

AU - Kamara, A.

AU - Kargbo, D.

AU - Caddy, S. L.

AU - Arias, Armando

AU - Thorne, L.

AU - Lu, J.

AU - Jah, U.

AU - Goodfellow, I.

AU - Koopmans, M. P.

PY - 2015

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AB - The Magazine Wharf area, Freetown, Sierra Leone was a focus of ongoing Ebola virus transmission from late June 2015. Viral genomes linked to this area contain a series of 13 T to C substitutions in a 150 base pair intergenic region downstream of viral protein 40 open reading frame, similar to the Ebolavirus/H.sapienswt/ SLE/2014/Makona-J0169 strain (J0169) detected in the same town in November 2014. This suggests that recently circulating viruses from Freetown descend from a J0169-like virus.

KW - Epidemiology

KW - Public Health, Environmental and Occupational Health

KW - Virology

KW - Africa

KW - Article

KW - Ebola hemorrhagic fever

KW - Ebolavirus

KW - evolution

KW - genetic variability

KW - genome analysis

KW - haplotype

KW - human

KW - mutation

KW - nonhuman

KW - nucleotide sequence

KW - sequence alignment

KW - Sierra Leone

KW - virus genome

KW - virus strain

KW - Ebola virus

KW - surveillance

KW - viral infections

U2 - 10.2807/1560-7917.ES.2015.20.40.30035

DO - 10.2807/1560-7917.ES.2015.20.40.30035

M3 - Journal article

C2 - 26539753

SN - 1025-496X

VL - 20

JO - Eurosurveillance (Online Edition)

JF - Eurosurveillance (Online Edition)

IS - 40

ER -

Genotypic anomaly in ebola virus strains circulating in magazine wharf Area, Freetown, Sierra Leone, 2015

Abstract

Keywords

UN SDGs

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