Genomic Characterization of Campylobacter jejuni strain M1

Carsten Friis, Gertrude Maria Wassenaar, Muhammad A. Javed, Lars Snipen, Karin Lagesen, Peter Fischer Hallin, Diane G. Newell, Monique Toszeghy, Anne Ridley, Georgia Manning, David Ussery

    Research output: Contribution to journalJournal articleResearchpeer-review

    223 Downloads (Pure)

    Abstract

    Campylobacter jejuni strain M1 (laboratory designation 99/308) is a rarely documented case of direct transmission of C. jejuni from chicken to a person, resulting in enteritis. We have sequenced the genome of C. jejuni strain M1, and compared this to 12 other C. jejuni sequenced genomes currently publicly available. Compared to these, M1 is closest to strain 81116. Based on the 13 genome sequences, we have identified the C. jejuni pan-genome, as well as the core genome, the auxiliary genes, and genes unique between strains M1 and 81116. The pan-genome contains 2,427 gene families, whilst the core genome comprised 1,295 gene families, or about two-thirds of the gene content of the average of the sequenced C. jejuni genomes. Various comparison and visualization tools were applied to the 13 C. jejuni genome sequences, including a species pan- and core genome plot, a BLAST Matrix and a BLAST Atlas. Trees based on 16S rRNA sequences and on the total gene families in each genome are presented. The findings are discussed in the background of the proven virulence potential of M1.
    Original languageEnglish
    JournalP L o S One
    Volume5
    Issue number8
    ISSN1932-6203
    DOIs
    Publication statusPublished - 2010

    Bibliographical note

    This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

    Cite this

    Friis, C., Wassenaar, G. M., Javed, M. A., Snipen, L., Lagesen, K., Hallin, P. F., Newell, D. G., Toszeghy, M., Ridley, A., Manning, G., & Ussery, D. (2010). Genomic Characterization of Campylobacter jejuni strain M1. P L o S One, 5(8). https://doi.org/10.1371/journal.pone.0012253