Genomic Analysis of Two-Component Signal Transduction Proteins in Basidiomycetes

David Ussery, JL Lavín, Tim Terence Binnewies, AG Pisabarro, JA Oguiza

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Two-component system (TCS) proteins are components of complex signal transduction pathways in fungi, and play essential roles in the regulation of several cellular functions and responses. Species of basidiomycetes have a marked variation in their specific physiological traits, morphological complexity and lifestyles. In this study, we have used the available complete genomes of basidiomycetes to carry out a thorough identification and an extensive comparative analysis of the TCS proteins in this fungal phylum. In comparison with ascomycetes, basidiomycetes exhibit an intermediate number of TCS proteins. Several TCS proteins are highly conserved among all the basidiomycetes, and other TCS proteins appear to be specific to particular species of basidiomycetes. Moreover, some species appear to have developed a unique histidine kinase group with unusual domain architecture, the Dual-histidine kinases. The presence of differential sets of TCS proteins between basidiomycete species might reflect their adaptation to diverse environmental niches
    Original languageEnglish
    JournalVeterinary Microbiology
    Volume18
    Issue number2
    Pages (from-to)63-73
    ISSN0378-1135
    DOIs
    Publication statusPublished - 2010

    Keywords

    • Histidine kinase
    • Basidiomycetes
    • Response regulator
    • Genomic analysis
    • Signal transduction
    • Comparative genomics

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