Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Verneri Anttila, Bendik S Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E Medland, Unda Todt, Wendy L McArdle, Lydia Quaye, Markku Koiranen, M Arfan Ikram, Terho Lehtimäki, Anine H Stam, Lannie Ligthart, Juho Wedenoja & 75 others Ian Dunham, Benjamin M Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E Buring, Paul M Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A Lawlor, David M Evans, Susan M Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R Frants, Nadine Pelzer, Claudia M Weller, Ronald Zielman, Andrew C Heath, Pamela A F Madden, Grant W Montgomery, Nicholas G Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze-Kuhn, Frances M K Williams, Anna-Liisa Hartikainen, Anneli Pouta, Joyce van den Ende, Andre G Uitterlinden, Albert Hofman, Najaf Amin, Jouke-Jan Hottenga, Jacqueline M Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G Eriksson, Bryan J Traynor, Daniah Trabzuni, Elizabeth Rossin, Kasper Lage Hansen, Suzanne B R Jacobs, J Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W Penninx, Dorret I Boomsma, Cornelia van Duijn, Olli Raitakari, Marjo-Riitta Jarvelin, John-Anker Zwart, Lynn Cherkas, David P Strachan, Christian Kubisch, Michel D Ferrari, Arn M J M van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J Daly, Dale R Nyholt, Daniel I Chasman, Aarno Palotie

    Research output: Contribution to journalJournal articleResearchpeer-review

    Abstract

    Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
    Original languageEnglish
    JournalNature Genetics
    Volume45
    Issue number8
    ISSN1061-4036
    DOIs
    Publication statusPublished - 2013

    Cite this

    Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., ... Palotie, A. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8). https://doi.org/10.1038/ng.2676
    Anttila, Verneri ; Winsvold, Bendik S ; Gormley, Padhraig ; Kurth, Tobias ; Bettella, Francesco ; McMahon, George ; Kallela, Mikko ; Malik, Rainer ; de Vries, Boukje ; Terwindt, Gisela ; Medland, Sarah E ; Todt, Unda ; McArdle, Wendy L ; Quaye, Lydia ; Koiranen, Markku ; Ikram, M Arfan ; Lehtimäki, Terho ; Stam, Anine H ; Ligthart, Lannie ; Wedenoja, Juho ; Dunham, Ian ; Neale, Benjamin M ; Palta, Priit ; Hamalainen, Eija ; Schürks, Markus ; Rose, Lynda M ; Buring, Julie E ; Ridker, Paul M ; Steinberg, Stacy ; Stefansson, Hreinn ; Jakobsson, Finnbogi ; Lawlor, Debbie A ; Evans, David M ; Ring, Susan M ; Färkkilä, Markus ; Artto, Ville ; Kaunisto, Mari A ; Freilinger, Tobias ; Schoenen, Jean ; Frants, Rune R ; Pelzer, Nadine ; Weller, Claudia M ; Zielman, Ronald ; Heath, Andrew C ; Madden, Pamela A F ; Montgomery, Grant W ; Martin, Nicholas G ; Borck, Guntram ; Göbel, Hartmut ; Heinze, Axel ; Heinze-Kuhn, Katja ; Williams, Frances M K ; Hartikainen, Anna-Liisa ; Pouta, Anneli ; van den Ende, Joyce ; Uitterlinden, Andre G ; Hofman, Albert ; Amin, Najaf ; Hottenga, Jouke-Jan ; Vink, Jacqueline M ; Heikkilä, Kauko ; Alexander, Michael ; Muller-Myhsok, Bertram ; Schreiber, Stefan ; Meitinger, Thomas ; Wichmann, Heinz Erich ; Aromaa, Arpo ; Eriksson, Johan G ; Traynor, Bryan J ; Trabzuni, Daniah ; Rossin, Elizabeth ; Hansen, Kasper Lage ; Jacobs, Suzanne B R ; Gibbs, J Raphael ; Birney, Ewan ; Kaprio, Jaakko ; Penninx, Brenda W ; Boomsma, Dorret I ; van Duijn, Cornelia ; Raitakari, Olli ; Jarvelin, Marjo-Riitta ; Zwart, John-Anker ; Cherkas, Lynn ; Strachan, David P ; Kubisch, Christian ; Ferrari, Michel D ; van den Maagdenberg, Arn M J M ; Dichgans, Martin ; Wessman, Maija ; Smith, George Davey ; Stefansson, Kari ; Daly, Mark J ; Nyholt, Dale R ; Chasman, Daniel I ; Palotie, Aarno. / Genome-wide meta-analysis identifies new susceptibility loci for migraine. In: Nature Genetics. 2013 ; Vol. 45, No. 8.
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    title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine.",
    abstract = "Migraine is the most common brain disorder, affecting approximately 14{\%} of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.",
    author = "Verneri Anttila and Winsvold, {Bendik S} and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George McMahon and Mikko Kallela and Rainer Malik and {de Vries}, Boukje and Gisela Terwindt and Medland, {Sarah E} and Unda Todt and McArdle, {Wendy L} and Lydia Quaye and Markku Koiranen and Ikram, {M Arfan} and Terho Lehtim{\"a}ki and Stam, {Anine H} and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Neale, {Benjamin M} and Priit Palta and Eija Hamalainen and Markus Sch{\"u}rks and Rose, {Lynda M} and Buring, {Julie E} and Ridker, {Paul M} and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Lawlor, {Debbie A} and Evans, {David M} and Ring, {Susan M} and Markus F{\"a}rkkil{\"a} and Ville Artto and Kaunisto, {Mari A} and Tobias Freilinger and Jean Schoenen and Frants, {Rune R} and Nadine Pelzer and Weller, {Claudia M} and Ronald Zielman and Heath, {Andrew C} and Madden, {Pamela A F} and Montgomery, {Grant W} and Martin, {Nicholas G} and Guntram Borck and Hartmut G{\"o}bel and Axel Heinze and Katja Heinze-Kuhn and Williams, {Frances M K} and Anna-Liisa Hartikainen and Anneli Pouta and {van den Ende}, Joyce and Uitterlinden, {Andre G} and Albert Hofman and Najaf Amin and Jouke-Jan Hottenga and Vink, {Jacqueline M} and Kauko Heikkil{\"a} and Michael Alexander and Bertram Muller-Myhsok and Stefan Schreiber and Thomas Meitinger and Wichmann, {Heinz Erich} and Arpo Aromaa and Eriksson, {Johan G} and Traynor, {Bryan J} and Daniah Trabzuni and Elizabeth Rossin and Hansen, {Kasper Lage} and Jacobs, {Suzanne B R} and Gibbs, {J Raphael} and Ewan Birney and Jaakko Kaprio and Penninx, {Brenda W} and Boomsma, {Dorret I} and {van Duijn}, Cornelia and Olli Raitakari and Marjo-Riitta Jarvelin and John-Anker Zwart and Lynn Cherkas and Strachan, {David P} and Christian Kubisch and Ferrari, {Michel D} and {van den Maagdenberg}, {Arn M J M} and Martin Dichgans and Maija Wessman and Smith, {George Davey} and Kari Stefansson and Daly, {Mark J} and Nyholt, {Dale R} and Chasman, {Daniel I} and Aarno Palotie",
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    journal = "Nature Genetics",
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    Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, de Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, MA, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Göbel, H, Heinze, A, Heinze-Kuhn, K, Williams, FMK, Hartikainen, A-L, Pouta, A, van den Ende, J, Uitterlinden, AG, Hofman, A, Amin, N, Hottenga, J-J, Vink, JM, Heikkilä, K, Alexander, M, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Wichmann, HE, Aromaa, A, Eriksson, JG, Traynor, BJ, Trabzuni, D, Rossin, E, Hansen, KL, Jacobs, SBR, Gibbs, JR, Birney, E, Kaprio, J, Penninx, BW, Boomsma, DI, van Duijn, C, Raitakari, O, Jarvelin, M-R, Zwart, J-A, Cherkas, L, Strachan, DP, Kubisch, C, Ferrari, MD, van den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Daly, MJ, Nyholt, DR, Chasman, DI & Palotie, A 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine.', Nature Genetics, vol. 45, no. 8. https://doi.org/10.1038/ng.2676

    Genome-wide meta-analysis identifies new susceptibility loci for migraine. / Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimäki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho; Dunham, Ian; Neale, Benjamin M; Palta, Priit; Hamalainen, Eija; Schürks, Markus; Rose, Lynda M; Buring, Julie E; Ridker, Paul M; Steinberg, Stacy; Stefansson, Hreinn; Jakobsson, Finnbogi; Lawlor, Debbie A; Evans, David M; Ring, Susan M; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari A; Freilinger, Tobias; Schoenen, Jean; Frants, Rune R; Pelzer, Nadine; Weller, Claudia M; Zielman, Ronald; Heath, Andrew C; Madden, Pamela A F; Montgomery, Grant W; Martin, Nicholas G; Borck, Guntram; Göbel, Hartmut; Heinze, Axel; Heinze-Kuhn, Katja; Williams, Frances M K; Hartikainen, Anna-Liisa; Pouta, Anneli; van den Ende, Joyce; Uitterlinden, Andre G; Hofman, Albert; Amin, Najaf; Hottenga, Jouke-Jan; Vink, Jacqueline M; Heikkilä, Kauko; Alexander, Michael; Muller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Wichmann, Heinz Erich; Aromaa, Arpo; Eriksson, Johan G; Traynor, Bryan J; Trabzuni, Daniah; Rossin, Elizabeth; Hansen, Kasper Lage; Jacobs, Suzanne B R; Gibbs, J Raphael; Birney, Ewan; Kaprio, Jaakko; Penninx, Brenda W; Boomsma, Dorret I; van Duijn, Cornelia; Raitakari, Olli; Jarvelin, Marjo-Riitta; Zwart, John-Anker; Cherkas, Lynn; Strachan, David P; Kubisch, Christian; Ferrari, Michel D; van den Maagdenberg, Arn M J M; Dichgans, Martin; Wessman, Maija; Smith, George Davey; Stefansson, Kari; Daly, Mark J; Nyholt, Dale R; Chasman, Daniel I; Palotie, Aarno.

    In: Nature Genetics, Vol. 45, No. 8, 2013.

    Research output: Contribution to journalJournal articleResearchpeer-review

    TY - JOUR

    T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine.

    AU - Anttila, Verneri

    AU - Winsvold, Bendik S

    AU - Gormley, Padhraig

    AU - Kurth, Tobias

    AU - Bettella, Francesco

    AU - McMahon, George

    AU - Kallela, Mikko

    AU - Malik, Rainer

    AU - de Vries, Boukje

    AU - Terwindt, Gisela

    AU - Medland, Sarah E

    AU - Todt, Unda

    AU - McArdle, Wendy L

    AU - Quaye, Lydia

    AU - Koiranen, Markku

    AU - Ikram, M Arfan

    AU - Lehtimäki, Terho

    AU - Stam, Anine H

    AU - Ligthart, Lannie

    AU - Wedenoja, Juho

    AU - Dunham, Ian

    AU - Neale, Benjamin M

    AU - Palta, Priit

    AU - Hamalainen, Eija

    AU - Schürks, Markus

    AU - Rose, Lynda M

    AU - Buring, Julie E

    AU - Ridker, Paul M

    AU - Steinberg, Stacy

    AU - Stefansson, Hreinn

    AU - Jakobsson, Finnbogi

    AU - Lawlor, Debbie A

    AU - Evans, David M

    AU - Ring, Susan M

    AU - Färkkilä, Markus

    AU - Artto, Ville

    AU - Kaunisto, Mari A

    AU - Freilinger, Tobias

    AU - Schoenen, Jean

    AU - Frants, Rune R

    AU - Pelzer, Nadine

    AU - Weller, Claudia M

    AU - Zielman, Ronald

    AU - Heath, Andrew C

    AU - Madden, Pamela A F

    AU - Montgomery, Grant W

    AU - Martin, Nicholas G

    AU - Borck, Guntram

    AU - Göbel, Hartmut

    AU - Heinze, Axel

    AU - Heinze-Kuhn, Katja

    AU - Williams, Frances M K

    AU - Hartikainen, Anna-Liisa

    AU - Pouta, Anneli

    AU - van den Ende, Joyce

    AU - Uitterlinden, Andre G

    AU - Hofman, Albert

    AU - Amin, Najaf

    AU - Hottenga, Jouke-Jan

    AU - Vink, Jacqueline M

    AU - Heikkilä, Kauko

    AU - Alexander, Michael

    AU - Muller-Myhsok, Bertram

    AU - Schreiber, Stefan

    AU - Meitinger, Thomas

    AU - Wichmann, Heinz Erich

    AU - Aromaa, Arpo

    AU - Eriksson, Johan G

    AU - Traynor, Bryan J

    AU - Trabzuni, Daniah

    AU - Rossin, Elizabeth

    AU - Hansen, Kasper Lage

    AU - Jacobs, Suzanne B R

    AU - Gibbs, J Raphael

    AU - Birney, Ewan

    AU - Kaprio, Jaakko

    AU - Penninx, Brenda W

    AU - Boomsma, Dorret I

    AU - van Duijn, Cornelia

    AU - Raitakari, Olli

    AU - Jarvelin, Marjo-Riitta

    AU - Zwart, John-Anker

    AU - Cherkas, Lynn

    AU - Strachan, David P

    AU - Kubisch, Christian

    AU - Ferrari, Michel D

    AU - van den Maagdenberg, Arn M J M

    AU - Dichgans, Martin

    AU - Wessman, Maija

    AU - Smith, George Davey

    AU - Stefansson, Kari

    AU - Daly, Mark J

    AU - Nyholt, Dale R

    AU - Chasman, Daniel I

    AU - Palotie, Aarno

    PY - 2013

    Y1 - 2013

    N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

    AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

    U2 - 10.1038/ng.2676

    DO - 10.1038/ng.2676

    M3 - Journal article

    VL - 45

    JO - Nature Genetics

    JF - Nature Genetics

    SN - 1061-4036

    IS - 8

    ER -

    Anttila V, Winsvold BS, Gormley P, Kurth T, Bettella F, McMahon G et al. Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics. 2013;45(8). https://doi.org/10.1038/ng.2676