Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Verneri Anttila; Bendik S Winsvold; Padhraig Gormley; Tobias Kurth; Francesco Bettella; George McMahon; Mikko Kallela; Rainer Malik; Boukje de Vries; Gisela Terwindt; Sarah E Medland; Unda Todt; Wendy L McArdle; Lydia Quaye; Markku Koiranen; M Arfan Ikram; Terho Lehtimäki; Anine H Stam; Lannie Ligthart; Juho Wedenoja; Ian Dunham; Benjamin M Neale; Priit Palta; Eija Hamalainen; Markus Schürks; Lynda M Rose; Julie E Buring; Paul M Ridker; Stacy Steinberg; Hreinn Stefansson; Finnbogi Jakobsson; Debbie A Lawlor; David M Evans; Susan M Ring; Markus Färkkilä; Ville Artto; Mari A Kaunisto; Tobias Freilinger; Jean Schoenen; Rune R Frants; Nadine Pelzer; Claudia M Weller; Ronald Zielman; Andrew C Heath; Pamela A F Madden; Grant W Montgomery; Nicholas G Martin; Guntram Borck; Hartmut Göbel; Axel Heinze; Katja Heinze-Kuhn; Frances M K Williams; Anna-Liisa Hartikainen; Anneli Pouta; Joyce van den Ende; Andre G Uitterlinden; Albert Hofman; Najaf Amin; Jouke-Jan Hottenga; Jacqueline M Vink; Kauko Heikkilä; Michael Alexander; Bertram Muller-Myhsok; Stefan Schreiber; Thomas Meitinger; Heinz Erich Wichmann; Arpo Aromaa; Johan G Eriksson; Bryan J Traynor; Daniah Trabzuni; Elizabeth Rossin; Kasper Lage Hansen; Suzanne B R Jacobs; J Raphael Gibbs; Ewan Birney; Jaakko Kaprio; Brenda W Penninx; Dorret I Boomsma; Cornelia van Duijn; Olli Raitakari; Marjo-Riitta Jarvelin; John-Anker Zwart; Lynn Cherkas; David P Strachan; Christian Kubisch; Michel D Ferrari; Arn M J M van den Maagdenberg; Martin Dichgans; Maija Wessman; George Davey Smith; Kari Stefansson; Mark J Daly; Dale R Nyholt; Daniel I Chasman; Aarno Palotie

doi:10.1038/ng.2676

Genome-wide meta-analysis identifies new susceptibility loci for migraine.

Verneri Anttila, Bendik S Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E Medland, Unda Todt, Wendy L McArdle, Lydia Quaye, Markku Koiranen, M Arfan Ikram, Terho Lehtimäki, Anine H Stam, Lannie Ligthart, Juho WedenojaIan Dunham, Benjamin M Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E Buring, Paul M Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A Lawlor, David M Evans, Susan M Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R Frants, Nadine Pelzer, Claudia M Weller, Ronald Zielman, Andrew C Heath, Pamela A F Madden, Grant W Montgomery, Nicholas G Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze-Kuhn, Frances M K Williams, Anna-Liisa Hartikainen, Anneli Pouta, Joyce van den Ende, Andre G Uitterlinden, Albert Hofman, Najaf Amin, Jouke-Jan Hottenga, Jacqueline M Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G Eriksson, Bryan J Traynor, Daniah Trabzuni, Elizabeth Rossin, Kasper Lage Hansen, Suzanne B R Jacobs, J Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W Penninx, Dorret I Boomsma, Cornelia van Duijn, Olli Raitakari, Marjo-Riitta Jarvelin, John-Anker Zwart, Lynn Cherkas, David P Strachan, Christian Kubisch, Michel D Ferrari, Arn M J M van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J Daly, Dale R Nyholt, Daniel I Chasman, Aarno Palotie

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

Original language	English
Journal	Nature Genetics
Volume	45
Issue number	8
ISSN	1061-4036
DOIs	https://doi.org/10.1038/ng.2676
Publication status	Published - 2013

Access to Document

10.1038/ng.2676

Fingerprint Dive into the research topics of 'Genome-wide meta-analysis identifies new susceptibility loci for migraine.'. Together they form a unique fingerprint.

Cite this

Anttila, V., Winsvold, B. S., Gormley, P., Kurth, T., Bettella, F., McMahon, G., Kallela, M., Malik, R., de Vries, B., Terwindt, G., Medland, S. E., Todt, U., McArdle, W. L., Quaye, L., Koiranen, M., Ikram, M. A., Lehtimäki, T., Stam, A. H., Ligthart, L., ... Palotie, A. (2013). Genome-wide meta-analysis identifies new susceptibility loci for migraine. Nature Genetics, 45(8). https://doi.org/10.1038/ng.2676

Anttila, Verneri ; Winsvold, Bendik S ; Gormley, Padhraig ; Kurth, Tobias ; Bettella, Francesco ; McMahon, George ; Kallela, Mikko ; Malik, Rainer ; de Vries, Boukje ; Terwindt, Gisela ; Medland, Sarah E ; Todt, Unda ; McArdle, Wendy L ; Quaye, Lydia ; Koiranen, Markku ; Ikram, M Arfan ; Lehtimäki, Terho ; Stam, Anine H ; Ligthart, Lannie ; Wedenoja, Juho ; Dunham, Ian ; Neale, Benjamin M ; Palta, Priit ; Hamalainen, Eija ; Schürks, Markus ; Rose, Lynda M ; Buring, Julie E ; Ridker, Paul M ; Steinberg, Stacy ; Stefansson, Hreinn ; Jakobsson, Finnbogi ; Lawlor, Debbie A ; Evans, David M ; Ring, Susan M ; Färkkilä, Markus ; Artto, Ville ; Kaunisto, Mari A ; Freilinger, Tobias ; Schoenen, Jean ; Frants, Rune R ; Pelzer, Nadine ; Weller, Claudia M ; Zielman, Ronald ; Heath, Andrew C ; Madden, Pamela A F ; Montgomery, Grant W ; Martin, Nicholas G ; Borck, Guntram ; Göbel, Hartmut ; Heinze, Axel ; Heinze-Kuhn, Katja ; Williams, Frances M K ; Hartikainen, Anna-Liisa ; Pouta, Anneli ; van den Ende, Joyce ; Uitterlinden, Andre G ; Hofman, Albert ; Amin, Najaf ; Hottenga, Jouke-Jan ; Vink, Jacqueline M ; Heikkilä, Kauko ; Alexander, Michael ; Muller-Myhsok, Bertram ; Schreiber, Stefan ; Meitinger, Thomas ; Wichmann, Heinz Erich ; Aromaa, Arpo ; Eriksson, Johan G ; Traynor, Bryan J ; Trabzuni, Daniah ; Rossin, Elizabeth ; Hansen, Kasper Lage ; Jacobs, Suzanne B R ; Gibbs, J Raphael ; Birney, Ewan ; Kaprio, Jaakko ; Penninx, Brenda W ; Boomsma, Dorret I ; van Duijn, Cornelia ; Raitakari, Olli ; Jarvelin, Marjo-Riitta ; Zwart, John-Anker ; Cherkas, Lynn ; Strachan, David P ; Kubisch, Christian ; Ferrari, Michel D ; van den Maagdenberg, Arn M J M ; Dichgans, Martin ; Wessman, Maija ; Smith, George Davey ; Stefansson, Kari ; Daly, Mark J ; Nyholt, Dale R ; Chasman, Daniel I ; Palotie, Aarno. / Genome-wide meta-analysis identifies new susceptibility loci for migraine. In: Nature Genetics. 2013 ; Vol. 45, No. 8.

@article{525289ba2f2146faaf55f0a48ebe0ac5,

title = "Genome-wide meta-analysis identifies new susceptibility loci for migraine.",

abstract = "Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.",

author = "Verneri Anttila and Winsvold, {Bendik S} and Padhraig Gormley and Tobias Kurth and Francesco Bettella and George McMahon and Mikko Kallela and Rainer Malik and {de Vries}, Boukje and Gisela Terwindt and Medland, {Sarah E} and Unda Todt and McArdle, {Wendy L} and Lydia Quaye and Markku Koiranen and Ikram, {M Arfan} and Terho Lehtim{\"a}ki and Stam, {Anine H} and Lannie Ligthart and Juho Wedenoja and Ian Dunham and Neale, {Benjamin M} and Priit Palta and Eija Hamalainen and Markus Sch{\"u}rks and Rose, {Lynda M} and Buring, {Julie E} and Ridker, {Paul M} and Stacy Steinberg and Hreinn Stefansson and Finnbogi Jakobsson and Lawlor, {Debbie A} and Evans, {David M} and Ring, {Susan M} and Markus F{\"a}rkkil{\"a} and Ville Artto and Kaunisto, {Mari A} and Tobias Freilinger and Jean Schoenen and Frants, {Rune R} and Nadine Pelzer and Weller, {Claudia M} and Ronald Zielman and Heath, {Andrew C} and Madden, {Pamela A F} and Montgomery, {Grant W} and Martin, {Nicholas G} and Guntram Borck and Hartmut G{\"o}bel and Axel Heinze and Katja Heinze-Kuhn and Williams, {Frances M K} and Anna-Liisa Hartikainen and Anneli Pouta and {van den Ende}, Joyce and Uitterlinden, {Andre G} and Albert Hofman and Najaf Amin and Jouke-Jan Hottenga and Vink, {Jacqueline M} and Kauko Heikkil{\"a} and Michael Alexander and Bertram Muller-Myhsok and Stefan Schreiber and Thomas Meitinger and Wichmann, {Heinz Erich} and Arpo Aromaa and Eriksson, {Johan G} and Traynor, {Bryan J} and Daniah Trabzuni and Elizabeth Rossin and Hansen, {Kasper Lage} and Jacobs, {Suzanne B R} and Gibbs, {J Raphael} and Ewan Birney and Jaakko Kaprio and Penninx, {Brenda W} and Boomsma, {Dorret I} and {van Duijn}, Cornelia and Olli Raitakari and Marjo-Riitta Jarvelin and John-Anker Zwart and Lynn Cherkas and Strachan, {David P} and Christian Kubisch and Ferrari, {Michel D} and {van den Maagdenberg}, {Arn M J M} and Martin Dichgans and Maija Wessman and Smith, {George Davey} and Kari Stefansson and Daly, {Mark J} and Nyholt, {Dale R} and Chasman, {Daniel I} and Aarno Palotie",

year = "2013",

doi = "10.1038/ng.2676",

language = "English",

volume = "45",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Publishing Group",

number = "8",

}

Anttila, V, Winsvold, BS, Gormley, P, Kurth, T, Bettella, F, McMahon, G, Kallela, M, Malik, R, de Vries, B, Terwindt, G, Medland, SE, Todt, U, McArdle, WL, Quaye, L, Koiranen, M, Ikram, MA, Lehtimäki, T, Stam, AH, Ligthart, L, Wedenoja, J, Dunham, I, Neale, BM, Palta, P, Hamalainen, E, Schürks, M, Rose, LM, Buring, JE, Ridker, PM, Steinberg, S, Stefansson, H, Jakobsson, F, Lawlor, DA, Evans, DM, Ring, SM, Färkkilä, M, Artto, V, Kaunisto, MA, Freilinger, T, Schoenen, J, Frants, RR, Pelzer, N, Weller, CM, Zielman, R, Heath, AC, Madden, PAF, Montgomery, GW, Martin, NG, Borck, G, Göbel, H, Heinze, A, Heinze-Kuhn, K, Williams, FMK, Hartikainen, A-L, Pouta, A, van den Ende, J, Uitterlinden, AG, Hofman, A, Amin, N, Hottenga, J-J, Vink, JM, Heikkilä, K, Alexander, M, Muller-Myhsok, B, Schreiber, S, Meitinger, T, Wichmann, HE, Aromaa, A, Eriksson, JG, Traynor, BJ, Trabzuni, D, Rossin, E, Hansen, KL, Jacobs, SBR, Gibbs, JR, Birney, E, Kaprio, J, Penninx, BW, Boomsma, DI, van Duijn, C, Raitakari, O, Jarvelin, M-R, Zwart, J-A, Cherkas, L, Strachan, DP, Kubisch, C, Ferrari, MD, van den Maagdenberg, AMJM, Dichgans, M, Wessman, M, Smith, GD, Stefansson, K, Daly, MJ, Nyholt, DR, Chasman, DI & Palotie, A 2013, 'Genome-wide meta-analysis identifies new susceptibility loci for migraine.', Nature Genetics, vol. 45, no. 8. https://doi.org/10.1038/ng.2676

Genome-wide meta-analysis identifies new susceptibility loci for migraine. / Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimäki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho; Dunham, Ian; Neale, Benjamin M; Palta, Priit; Hamalainen, Eija; Schürks, Markus; Rose, Lynda M; Buring, Julie E; Ridker, Paul M; Steinberg, Stacy; Stefansson, Hreinn; Jakobsson, Finnbogi; Lawlor, Debbie A; Evans, David M; Ring, Susan M; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari A; Freilinger, Tobias; Schoenen, Jean; Frants, Rune R; Pelzer, Nadine; Weller, Claudia M; Zielman, Ronald; Heath, Andrew C; Madden, Pamela A F; Montgomery, Grant W; Martin, Nicholas G; Borck, Guntram; Göbel, Hartmut; Heinze, Axel; Heinze-Kuhn, Katja; Williams, Frances M K; Hartikainen, Anna-Liisa; Pouta, Anneli; van den Ende, Joyce; Uitterlinden, Andre G; Hofman, Albert; Amin, Najaf; Hottenga, Jouke-Jan; Vink, Jacqueline M; Heikkilä, Kauko; Alexander, Michael; Muller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Wichmann, Heinz Erich; Aromaa, Arpo; Eriksson, Johan G; Traynor, Bryan J; Trabzuni, Daniah; Rossin, Elizabeth; Hansen, Kasper Lage; Jacobs, Suzanne B R; Gibbs, J Raphael; Birney, Ewan; Kaprio, Jaakko; Penninx, Brenda W; Boomsma, Dorret I; van Duijn, Cornelia; Raitakari, Olli; Jarvelin, Marjo-Riitta; Zwart, John-Anker; Cherkas, Lynn; Strachan, David P; Kubisch, Christian; Ferrari, Michel D; van den Maagdenberg, Arn M J M; Dichgans, Martin; Wessman, Maija; Smith, George Davey; Stefansson, Kari; Daly, Mark J; Nyholt, Dale R; Chasman, Daniel I; Palotie, Aarno.

In: Nature Genetics, Vol. 45, No. 8, 2013.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine.

AU - Anttila, Verneri

AU - Winsvold, Bendik S

AU - Gormley, Padhraig

AU - Kurth, Tobias

AU - Bettella, Francesco

AU - McMahon, George

AU - Kallela, Mikko

AU - Malik, Rainer

AU - de Vries, Boukje

AU - Terwindt, Gisela

AU - Medland, Sarah E

AU - Todt, Unda

AU - McArdle, Wendy L

AU - Quaye, Lydia

AU - Koiranen, Markku

AU - Ikram, M Arfan

AU - Lehtimäki, Terho

AU - Stam, Anine H

AU - Ligthart, Lannie

AU - Wedenoja, Juho

AU - Dunham, Ian

AU - Neale, Benjamin M

AU - Palta, Priit

AU - Hamalainen, Eija

AU - Schürks, Markus

AU - Rose, Lynda M

AU - Buring, Julie E

AU - Ridker, Paul M

AU - Steinberg, Stacy

AU - Stefansson, Hreinn

AU - Jakobsson, Finnbogi

AU - Lawlor, Debbie A

AU - Evans, David M

AU - Ring, Susan M

AU - Färkkilä, Markus

AU - Artto, Ville

AU - Kaunisto, Mari A

AU - Freilinger, Tobias

AU - Schoenen, Jean

AU - Frants, Rune R

AU - Pelzer, Nadine

AU - Weller, Claudia M

AU - Zielman, Ronald

AU - Heath, Andrew C

AU - Madden, Pamela A F

AU - Montgomery, Grant W

AU - Martin, Nicholas G

AU - Borck, Guntram

AU - Göbel, Hartmut

AU - Heinze, Axel

AU - Heinze-Kuhn, Katja

AU - Williams, Frances M K

AU - Hartikainen, Anna-Liisa

AU - Pouta, Anneli

AU - van den Ende, Joyce

AU - Uitterlinden, Andre G

AU - Hofman, Albert

AU - Amin, Najaf

AU - Hottenga, Jouke-Jan

AU - Vink, Jacqueline M

AU - Heikkilä, Kauko

AU - Alexander, Michael

AU - Muller-Myhsok, Bertram

AU - Schreiber, Stefan

AU - Meitinger, Thomas

AU - Wichmann, Heinz Erich

AU - Aromaa, Arpo

AU - Eriksson, Johan G

AU - Traynor, Bryan J

AU - Trabzuni, Daniah

AU - Rossin, Elizabeth

AU - Hansen, Kasper Lage

AU - Jacobs, Suzanne B R

AU - Gibbs, J Raphael

AU - Birney, Ewan

AU - Kaprio, Jaakko

AU - Penninx, Brenda W

AU - Boomsma, Dorret I

AU - van Duijn, Cornelia

AU - Raitakari, Olli

AU - Jarvelin, Marjo-Riitta

AU - Zwart, John-Anker

AU - Cherkas, Lynn

AU - Strachan, David P

AU - Kubisch, Christian

AU - Ferrari, Michel D

AU - van den Maagdenberg, Arn M J M

AU - Dichgans, Martin

AU - Wessman, Maija

AU - Smith, George Davey

AU - Stefansson, Kari

AU - Daly, Mark J

AU - Nyholt, Dale R

AU - Chasman, Daniel I

AU - Palotie, Aarno

PY - 2013

Y1 - 2013

N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.

U2 - 10.1038/ng.2676

DO - 10.1038/ng.2676

M3 - Journal article

C2 - 23793025

VL - 45

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 8

ER -