Abstract
| Original language | English |
|---|---|
| Journal | Nature Genetics |
| Volume | 45 |
| Issue number | 8 |
| ISSN | 1061-4036 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Genome-wide meta-analysis identifies new susceptibility loci for migraine. / Anttila, Verneri; Winsvold, Bendik S; Gormley, Padhraig; Kurth, Tobias; Bettella, Francesco; McMahon, George; Kallela, Mikko; Malik, Rainer; de Vries, Boukje; Terwindt, Gisela; Medland, Sarah E; Todt, Unda; McArdle, Wendy L; Quaye, Lydia; Koiranen, Markku; Ikram, M Arfan; Lehtimäki, Terho; Stam, Anine H; Ligthart, Lannie; Wedenoja, Juho; Dunham, Ian; Neale, Benjamin M; Palta, Priit; Hamalainen, Eija; Schürks, Markus; Rose, Lynda M; Buring, Julie E; Ridker, Paul M; Steinberg, Stacy; Stefansson, Hreinn; Jakobsson, Finnbogi; Lawlor, Debbie A; Evans, David M; Ring, Susan M; Färkkilä, Markus; Artto, Ville; Kaunisto, Mari A; Freilinger, Tobias; Schoenen, Jean; Frants, Rune R; Pelzer, Nadine; Weller, Claudia M; Zielman, Ronald; Heath, Andrew C; Madden, Pamela A F; Montgomery, Grant W; Martin, Nicholas G; Borck, Guntram; Göbel, Hartmut; Heinze, Axel; Heinze-Kuhn, Katja; Williams, Frances M K; Hartikainen, Anna-Liisa; Pouta, Anneli; van den Ende, Joyce; Uitterlinden, Andre G; Hofman, Albert; Amin, Najaf; Hottenga, Jouke-Jan; Vink, Jacqueline M; Heikkilä, Kauko; Alexander, Michael; Muller-Myhsok, Bertram; Schreiber, Stefan; Meitinger, Thomas; Wichmann, Heinz Erich; Aromaa, Arpo; Eriksson, Johan G; Traynor, Bryan J; Trabzuni, Daniah; Rossin, Elizabeth; Hansen, Kasper Lage; Jacobs, Suzanne B R; Gibbs, J Raphael; Birney, Ewan; Kaprio, Jaakko; Penninx, Brenda W; Boomsma, Dorret I; van Duijn, Cornelia; Raitakari, Olli; Jarvelin, Marjo-Riitta; Zwart, John-Anker; Cherkas, Lynn; Strachan, David P; Kubisch, Christian; Ferrari, Michel D; van den Maagdenberg, Arn M J M; Dichgans, Martin; Wessman, Maija; Smith, George Davey; Stefansson, Kari; Daly, Mark J; Nyholt, Dale R; Chasman, Daniel I; Palotie, Aarno.
In: Nature Genetics, Vol. 45, No. 8, 2013.Research output: Contribution to journal › Journal article › Research › peer-review
TY - JOUR
T1 - Genome-wide meta-analysis identifies new susceptibility loci for migraine.
AU - Anttila, Verneri
AU - Winsvold, Bendik S
AU - Gormley, Padhraig
AU - Kurth, Tobias
AU - Bettella, Francesco
AU - McMahon, George
AU - Kallela, Mikko
AU - Malik, Rainer
AU - de Vries, Boukje
AU - Terwindt, Gisela
AU - Medland, Sarah E
AU - Todt, Unda
AU - McArdle, Wendy L
AU - Quaye, Lydia
AU - Koiranen, Markku
AU - Ikram, M Arfan
AU - Lehtimäki, Terho
AU - Stam, Anine H
AU - Ligthart, Lannie
AU - Wedenoja, Juho
AU - Dunham, Ian
AU - Neale, Benjamin M
AU - Palta, Priit
AU - Hamalainen, Eija
AU - Schürks, Markus
AU - Rose, Lynda M
AU - Buring, Julie E
AU - Ridker, Paul M
AU - Steinberg, Stacy
AU - Stefansson, Hreinn
AU - Jakobsson, Finnbogi
AU - Lawlor, Debbie A
AU - Evans, David M
AU - Ring, Susan M
AU - Färkkilä, Markus
AU - Artto, Ville
AU - Kaunisto, Mari A
AU - Freilinger, Tobias
AU - Schoenen, Jean
AU - Frants, Rune R
AU - Pelzer, Nadine
AU - Weller, Claudia M
AU - Zielman, Ronald
AU - Heath, Andrew C
AU - Madden, Pamela A F
AU - Montgomery, Grant W
AU - Martin, Nicholas G
AU - Borck, Guntram
AU - Göbel, Hartmut
AU - Heinze, Axel
AU - Heinze-Kuhn, Katja
AU - Williams, Frances M K
AU - Hartikainen, Anna-Liisa
AU - Pouta, Anneli
AU - van den Ende, Joyce
AU - Uitterlinden, Andre G
AU - Hofman, Albert
AU - Amin, Najaf
AU - Hottenga, Jouke-Jan
AU - Vink, Jacqueline M
AU - Heikkilä, Kauko
AU - Alexander, Michael
AU - Muller-Myhsok, Bertram
AU - Schreiber, Stefan
AU - Meitinger, Thomas
AU - Wichmann, Heinz Erich
AU - Aromaa, Arpo
AU - Eriksson, Johan G
AU - Traynor, Bryan J
AU - Trabzuni, Daniah
AU - Rossin, Elizabeth
AU - Hansen, Kasper Lage
AU - Jacobs, Suzanne B R
AU - Gibbs, J Raphael
AU - Birney, Ewan
AU - Kaprio, Jaakko
AU - Penninx, Brenda W
AU - Boomsma, Dorret I
AU - van Duijn, Cornelia
AU - Raitakari, Olli
AU - Jarvelin, Marjo-Riitta
AU - Zwart, John-Anker
AU - Cherkas, Lynn
AU - Strachan, David P
AU - Kubisch, Christian
AU - Ferrari, Michel D
AU - van den Maagdenberg, Arn M J M
AU - Dichgans, Martin
AU - Wessman, Maija
AU - Smith, George Davey
AU - Stefansson, Kari
AU - Daly, Mark J
AU - Nyholt, Dale R
AU - Chasman, Daniel I
AU - Palotie, Aarno
PY - 2013
Y1 - 2013
N2 - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
AB - Migraine is the most common brain disorder, affecting approximately 14% of the adult population, but its molecular mechanisms are poorly understood. We report the results of a meta-analysis across 29 genome-wide association studies, including a total of 23,285 individuals with migraine (cases) and 95,425 population-matched controls. We identified 12 loci associated with migraine susceptibility (P <5 × 10(-8)). Five loci are new: near AJAP1 at 1p36, near TSPAN2 at 1p13, within FHL5 at 6q16, within C7orf10 at 7p14 and near MMP16 at 8q21. Three of these loci were identified in disease subgroup analyses. Brain tissue expression quantitative trait locus analysis suggests potential functional candidate genes at four loci: APOA1BP, TBC1D7, FUT9, STAT6 and ATP5B.
U2 - 10.1038/ng.2676
DO - 10.1038/ng.2676
M3 - Journal article
VL - 45
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -