Genome-Wide Association Study in Dachshund: Identification of a Major Locus Affecting Intervertebral Disc Calcification

Mette Sloth Mogensen, Peter Karlskov-Mortensen, Helle Friis Proschowsky, Frode Lingaas, Anu Lappalainen, Hannes Lohi, Vibeke Frøkjær Jensen, Merete Fredholm

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Intervertebral disc calcification and herniation commonly affects Dachshund where the predisposition is caused by an early onset degenerative process resulting in disc calcification. A continuous spectrum of disc degeneration is seen within and among clog breeds, suggesting a multifactorial etiology. The number of calcified discs at 2 years of age determined by a radiographic evaluation is a good indicator of the severity of disc degeneration and thus serves as a measure for the risk of developing intervertebral disc herniation. The aim of the study was to identify genetic variants associated with intervertebral disc calcification in Dachshund through a genome-wide association (GWA) study. Based on thorough radiographic examinations, 48 cases with >= 6 disc calcifications or surgically treated for disc herniation and 46 controls with 0-1 disc calcifications were identified. GWA using the Illumina CanineHD BeadChip identified a locus on chromosome 12 from 36.8 to 38.6 Mb with 36 markers reaching genome-wide significance (P-genome = 0.00001-0.026). This study suggests that a major locus on chromosome 12 harbors genetic variations affecting the development of intervertebral disc calcification in Dachshund.
Original languageEnglish
JournalJournal of Heredity
Volume102
Pages (from-to)81-86
ISSN0022-1503
DOIs
Publication statusPublished - 2011

Fingerprint Dive into the research topics of 'Genome-Wide Association Study in Dachshund: Identification of a Major Locus Affecting Intervertebral Disc Calcification'. Together they form a unique fingerprint.

Cite this