Abstract
An introduction to genome-scale models, how to build and use them, will be
given in this chapter. Genome-scale models have become an important part of
systems biology and metabolic engineering, and are increasingly used in research,
both in academica and in industry, both for modeling chemical production and
for fundamental studies aiming at describing and explaining phenotypic behavior
of microbial and mammalian cells.
given in this chapter. Genome-scale models have become an important part of
systems biology and metabolic engineering, and are increasingly used in research,
both in academica and in industry, both for modeling chemical production and
for fundamental studies aiming at describing and explaining phenotypic behavior
of microbial and mammalian cells.
| Original language | English |
|---|---|
| Title of host publication | Fundamental Bioengineering |
| Editors | John Villadsen |
| Number of pages | 40 |
| Place of Publication | Weinheim, Germany |
| Publisher | Wiley-VCH |
| Publication date | 2016 |
| Edition | 1st edition |
| Pages | 143-182 |
| Chapter | 6 |
| ISBN (Print) | 9783527336746 |
| ISBN (Electronic) | 9783527697441 |
| DOIs | |
| Publication status | Published - 2016 |
| Series | Advanced Biotechnology |
|---|---|
| ISSN | 2365-3035 |
Keywords
- Annotated genome
- Eukaryotic models
- Genome-scale models
- Metabolic networks reconstruction
- Metabolome
- Model simulations
- Proteome
- Transcriptome
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