Abstract
Genome-scale metabolic models (GEMs) are mathematical models that enable systematic analysis of metabolism. This modeling concept has been applied to study the metabolism of many organisms including the eukaryal model organism, the yeast Saccharomyces cerevisiae, that also serves as an important cell factory for production of fuels and chemicals. With the application of yeast GEMs, our knowledge of metabolism is increasing. Therefore, GEMs have also been used for modeling human cells to study metabolic diseases. Here we introduce the concept of GEMs and provide a protocol for reconstructing GEMs. Besides, we show the historic development of yeast GEMs and their applications. Also, we review human GEMs as well as their uses in the studies of complex diseases.
| Original language | English |
|---|---|
| Title of host publication | Yeast Systems Biology |
| Volume | 2049 |
| Publication date | 2019 |
| Pages | 329-345 |
| DOIs | |
| Publication status | Published - 2019 |
| Series | Methods in Molecular Biology |
|---|---|
| ISSN | 1064-3745 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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