Abstract
Microorganisms
are
the
most
important
source
of
natural
products
with
antimicrobial
or
antitumor
activity.
These
natural
products
are
the
main
source
for
anti-‐infectives;
80%
of
antibiotics
currently
in
medical
use
are
derived
from
this
class
of
compounds.
In
the
past,
functional
screenings
aiming
directly
to
the
substances
or
to
putative
targets
were
the
only
possibility
to
identify
and
isolate
such
compounds.
With
the
recent
progress
of
sequencing
technologies,
genome
mining
has
become
a
very
important
method
to
complement
the
laborious
and
expensive
experimental
approach
and
to
broaden
the
biological
sources
for
novel
drug
candidates.
For
high-‐throughput
genome
mining,
sophisticated
software
is
required,
which
allows
the
prediction
of
putative
biosynthetic
products
based
on
genomic
data.
Here,
we
present
the
new
version
3
of
the
software
antiSMASH
(http://antismash.secondarymetabolites.org).
antiSMASH3
currently
is
the
most
comprehensive
automated
genome
mining
platform
for
natural
product
biosynthetic
pathways.
It
automatically
screens
genomic
data
of
bacteria
and
fungi
for
the
presence
of
24
different
types
of
secondary
metabolite
biosynthetic
pathways.
For
different
classes
of
secondary
metabolites,
detailed
analyses
on
domain
organization,
enzyme
active
sites,
and
substrate
specificities
are
integrated
in
the
pipeline
and
allow
the
prediction
of
the
biosynthetic
core-‐products
of
the
pathways.
In
addition
to
tools
focusing
on
the
enzymes
of
the
pathways,
the
identified
gene
clusters
are
searched
compared
against
different
integrated
databases
to
identify
homologous
(often
uncharacterized)
gene
clusters
in
other
microorganisms,
genes
encoding
the
biosynthesis
of
conserved
precursors
or
related
experimentally
validated
gene
clusters.
A
new
module
of
antiSMASH3
now
also
provides
a
direct
integration
of
metabolic
modeling
platform
covering
primary
and
secondary
metabolism.
| Original language | English |
|---|---|
| Title of host publication | Abstract Book - DTU Sustain Conference 2014 |
| Number of pages | 1 |
| Place of Publication | Kgs. Lyngby |
| Publisher | Technical University of Denmark |
| Publication date | 2014 |
| Publication status | Published - 2014 |
| Event | DTU Sustain Conference 2014 - Technical University of Denmark, Lyngby, Denmark Duration: 17 Dec 2014 → 17 Dec 2014 http://www.sustain.dtu.dk/ |
Conference
| Conference | DTU Sustain Conference 2014 |
|---|---|
| Location | Technical University of Denmark |
| Country/Territory | Denmark |
| City | Lyngby |
| Period | 17/12/2014 → 17/12/2014 |
| Internet address |