Genipin cross-linked carbon dots for antimicrobial, bioimaging and bacterial discrimination

Xiaohong Chu, Fan Wu, Baohong Sun, Ming Zhang, Saijie Song, Pan Zhang, Yuli Wang, Qicheng Zhang, Ninglin Zhou*, Jian Shen*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

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Multifunctional carbon dots (CDs) present enormous potential in numerous applications and have attracted widespread attention for various applications in the biomedical field. Bacterial infection is a common health issue; the development of antibacterial materials with low toxicity and good biocompatibility is becoming more important. In this work, we synthesized a new type of nitrogen co-doped carbon dots-genipin covalent conjugate (N-CDs-GP) via hydrothermal methods. The microstructure and chemical composition of the N-CDs-GP were characterized. The biocompatibility, stability, antibacterial activity, and fluorescence performance of the N-CDs-GP were assessed. The results revealed that N-CDs-GP possessed high biocompatibility, high light stability, and broad antibacterial activity. Additionally, selective Gram-positive bacterial imaging by N-CDs-GP provided a more rapid method of bacterial detection. The N-CDs-GP have the potential to be applied as bioimaging and antibacterial agents and for bacterial discrimination.
Original languageEnglish
Article number110930
JournalColloids and Surfaces B: Biointerfaces
Number of pages8
Publication statusPublished - 2020


  • Multifunctional carbon dots
  • Antibacterial activity
  • Bioimaging
  • Bacterial discrimination


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