Abstract
The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
| Original language | English |
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| IPC | C12N 15/ 00 A I |
| Patent number | WO2016120345 |
| Filing date | 04/08/2016 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 27/01/2015 |
| Priority number | EP20150152643 |
| Publication status | Published - 4 Aug 2016 |