Genetically engineered yeast

Irina Borodina (Inventor), Kanchana Rueksomtawin Kildegaard (Inventor), Jochen Förster (Inventor), Fredrik Öberg (Inventor)

Research output: Patent

Abstract

A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.
Original languageEnglish
IPCC12N15/52
Patent numberWO2014057036
Filing date17/04/2014
CountryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date11/10/2012
Priority numberEP20120188198
Publication statusPublished - 2014

Bibliographical note

Also published as: US2015267228 (A1); JP2015531237 (A); EP2906701 (A1); CN104884621 (A); CA2888093 (A1)

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