Genetically engineered yeast

Irina Borodina; Kanchana Rueksomtawin Kildegaard; Jochen Förster; Fredrik Öberg

Genetically engineered yeast

Irina Borodina (Inventor), Kanchana Rueksomtawin Kildegaard (Inventor), Jochen Förster (Inventor), Fredrik Öberg (Inventor)

Novo Nordisk Foundation Center for Biosustainability

Research output: Patent

Abstract

A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

Original language	English
IPC	C12N15/52
Patent number	WO2014057036
Filing date	17/04/2014
Country/Territory	International Bureau of the World Intellectual Property Organization (WIPO)
Priority date	11/10/2012
Priority number	EP20120188198
Publication status	Published - 2014

Bibliographical note

Also published as: US2015267228 (A1); JP2015531237 (A); EP2906701 (A1); CN104884621 (A); CA2888093 (A1)

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title = "Genetically engineered yeast",

abstract = "A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.",

author = "Irina Borodina and Kildegaard, {Kanchana Rueksomtawin} and Jochen F{\"o}rster and Fredrik {\"O}berg",

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TY - PAT

T1 - Genetically engineered yeast

AU - Borodina, Irina

AU - Kildegaard, Kanchana Rueksomtawin

AU - Förster, Jochen

AU - Öberg, Fredrik

N1 - Also published as: US2015267228 (A1); JP2015531237 (A); EP2906701 (A1); CN104884621 (A); CA2888093 (A1)

PY - 2014

Y1 - 2014

N2 - A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

AB - A genetically modified Saccharomyces cerevisiae comprising an active fermentation pathway producing 3-HP expresses an exogenous gene expressing the aminotransferase YhxA from Bacillus cereus AH1272 catalysing a transamination reaction between beta-alanine and pyruvate to produce malonate semialdehyde. The yeast may also express a 3-hydroxyisobutyrate dehydrogenase (HIBADH) and a 3-hydroxypropanoate dehydrogenase (3-HPDH) and aspartate 1-decarboxylase. Additionally the yeast may express pyruvate carboxylase and aspartate aminotransferase.

M3 - Patent

M1 - WO2014057036

Y2 - 2014/04/17

ER -

Genetically engineered yeast

Abstract

Bibliographical note

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