Genetically edited T-cell membrane coated AIEgen nanoparticles effectively prevents glioblastoma recurrence

Wentao Wang, Fan Wu, Mohsen Mohammadniaei, Ming Zhang*, Yuanyuan Li, Yi Sun, Ben Zhong Tang

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review


Glioblastoma stem cells (GSCs) are subpopulations of tumor-initiating cells responsible for glioblastoma (GBM) tumorigenesis and recurrence. Dual inhibition of vascular endothelium and GSCs is still a challenge due to their different pathological features. Here we present a combined all-in-control strategy to realize a local photothermal therapy (PTT). We designed T-cell-mimic nanoparticles with aggregation-induced emission (AIE) characteristics by coating the genetically engineered T cell membrane (CM) onto AIE nanoparticles (CM@AIE NPs). The CM shell was designed against CD133 and epidermal growth factor receptor (EGFR) which provides the possibility to target both GBM cells and GSCs for cancer therapy. CM@AIE NPs can serve as the tight junction (TJ) modulators to trigger an intracellular signaling cascade, causing TJ disruption and actin cytoskeleton reorganization to allow CM@AIE NPs to cross the blood-brain barrier (BBB) silently. The 980 nm excitation-triggered PTT can completely inhibit tumorigenesis and recurrence. The combination of CM-coating nanotechnology and genetic editing technique can inspire further development of synergetic techniques for preventing GBM recurrence.

Original languageEnglish
Article number121981
Number of pages10
Publication statusPublished - 2023


  • Aggregation-induced emission
  • Blood brain barrier
  • Glioblastoma
  • Glioblastoma stem cells
  • Photothermal therapy


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