Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children: Childhood Obesity Gene Risk: Intervention Outcome

Mette Hollensted, Mette Fogh, Theresia M Schnurr*, Julie T Kloppenborg, Christian T Have, Tenna Ruest Haarmark Nielsen, Johanne Rask, Morten Asp Vonsild Lund, Christine Frithioff-Bøjsøe, Mia Østergaard Johansen, Emil Vincent Rosenbaum Appel, Yuvaraj Mahendran, Niels Grarup, Haja N Kadarmideen, Oluf Pedersen, Jens-Christian Holm, Torben Hansen

*Corresponding author for this work

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    Abstract

    This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models. At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention. A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.
    Original languageEnglish
    JournalObesity
    Volume26
    Issue number12
    Pages (from-to)1915-1922
    ISSN1930-7381
    DOIs
    Publication statusPublished - 2018

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