TY - JOUR
T1 - Genetic Susceptibility for Childhood BMI has no Impact on Weight Loss Following Lifestyle Intervention in Danish Children
T2 - Childhood Obesity Gene Risk: Intervention Outcome
AU - Hollensted, Mette
AU - Fogh, Mette
AU - Schnurr, Theresia M
AU - Kloppenborg, Julie T
AU - Have, Christian T
AU - Ruest Haarmark Nielsen, Tenna
AU - Rask, Johanne
AU - Asp Vonsild Lund, Morten
AU - Frithioff-Bøjsøe, Christine
AU - Østergaard Johansen, Mia
AU - Vincent Rosenbaum Appel, Emil
AU - Mahendran, Yuvaraj
AU - Grarup, Niels
AU - Kadarmideen, Haja N
AU - Pedersen, Oluf
AU - Holm, Jens-Christian
AU - Hansen, Torben
PY - 2018
Y1 - 2018
N2 - This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models. At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention. A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.
AB - This study aimed to investigate the effect of a genetic risk score (GRS) comprising 15 single-nucleotide polymorphisms, previously shown to associate with childhood BMI, on the baseline cardiometabolic traits and the response to a lifestyle intervention in Danish children and adolescents. Children and adolescents with overweight or obesity (n = 920) and a population-based control sample (n = 698) were recruited. Anthropometric and biochemical measures were obtained at baseline and in a subgroup of children and adolescents with overweight or obesity again after 6 to 24 months of lifestyle intervention (n = 754). The effects of the GRS were examined by multiple linear regressions using additive genetic models. At baseline, the GRS associated with BMI standard deviation score (SDS) both in children and adolescents with overweight or obesity (β = 0.033 [SE = 0.01]; P = 0.001) and in the population-based sample (β = 0.065 [SE = 0.02]; P = 0.001). No associations were observed for cardiometabolic traits. The GRS did not influence changes in BMI SDS or cardiometabolic traits following lifestyle intervention. A GRS for childhood BMI was associated with BMI SDS but not with other cardiometabolic traits in Danish children and adolescents. The GRS did not influence treatment response following lifestyle intervention.
U2 - 10.1002/oby.22308
DO - 10.1002/oby.22308
M3 - Journal article
C2 - 30460774
VL - 26
SP - 1915
EP - 1922
JO - Obesity
JF - Obesity
SN - 1930-7381
IS - 12
ER -
