Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

L Nielsen; P Arctander; T H Jensen; H H Dietz; Anne Sofie Hammer; A C Banyard; T Barrett; M Blixenkrone-Møller

doi:10.1016/j.virusres.2009.04.023

Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

L Nielsen, P Arctander, T H Jensen, H H Dietz, Anne Sofie Hammer, A C Banyard, T Barrett, M Blixenkrone-Møller

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Abstract

To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic observed among seals in Danish Waters, we have sequenced wild-type genes of the attachment (H) glycoproteins of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover, upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic in Danish Waters was investigated and determined to be caused by canine distemper virus, the closest relative of PDV, revealing no direct epidemiological link to the seal epizootics. (C) 2009 Elsevier B.V. All rights reserved.

Original language	English
Journal	Virus Research
Volume	144
Issue number	1-2
Pages (from-to)	323-328
ISSN	0168-1702
DOIs	https://doi.org/10.1016/j.virusres.2009.04.023
Publication status	Published - 2009

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title = "Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics",

abstract = "To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic observed among seals in Danish Waters, we have sequenced wild-type genes of the attachment (H) glycoproteins of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover, upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic in Danish Waters was investigated and determined to be caused by canine distemper virus, the closest relative of PDV, revealing no direct epidemiological link to the seal epizootics. (C) 2009 Elsevier B.V. All rights reserved.",

author = "L Nielsen and P Arctander and Jensen, {T H} and Dietz, {H H} and Hammer, {Anne Sofie} and Banyard, {A C} and T Barrett and M Blixenkrone-M{\o}ller",

year = "2009",

doi = "10.1016/j.virusres.2009.04.023",

language = "English",

volume = "144",

pages = "323--328",

journal = "Virus Research",

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T1 - Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

AU - Nielsen, L

AU - Arctander, P

AU - Jensen, T H

AU - Dietz, H H

AU - Hammer, Anne Sofie

AU - Banyard, A C

AU - Barrett, T

AU - Blixenkrone-Møller, M

PY - 2009

Y1 - 2009

N2 - To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic observed among seals in Danish Waters, we have sequenced wild-type genes of the attachment (H) glycoproteins of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover, upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic in Danish Waters was investigated and determined to be caused by canine distemper virus, the closest relative of PDV, revealing no direct epidemiological link to the seal epizootics. (C) 2009 Elsevier B.V. All rights reserved.

AB - To investigate the possible origin and spread of the dramatic re-emergent 2002 distemper epizootic observed among seals in Danish Waters, we have sequenced wild-type genes of the attachment (H) glycoproteins of viruses from both the 2002 and 1988 epizootics. Phylogenetic analysis of the H genes of phocine distemper virus (PDV) together with other morbilliviruses, suggests that the re-emergent 2002 PDV is more closely related to a putative recent ancestral PDV than the 1988 PDV isolates. Moreover, upsurges of distemper disease in land-living carnivores linked in time and locality to the 2002 seal epizootic in Danish Waters was investigated and determined to be caused by canine distemper virus, the closest relative of PDV, revealing no direct epidemiological link to the seal epizootics. (C) 2009 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.virusres.2009.04.023

DO - 10.1016/j.virusres.2009.04.023

M3 - Journal article

SN - 0168-1702

VL - 144

SP - 323

EP - 328

JO - Virus Research

JF - Virus Research

IS - 1-2

ER -

Genetic diversity and phylogenetic analysis of the attachment glycoprotein of phocine distemper viruses of the 2002 and 1988 epizootics

Abstract

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