Abstract
A biosynthetic gene cluster of the fungal xanthone heterodimer neosartorin (1) was discovered in Aspergillus novofumigatus, and its biosynthesis was investigated by a series of gene-deletion experiments. The results indicate that the two monomeric units of 1 are synthesized by the same set of enzymes, with chrysophanol (5) as a common precursor. Furthermore, the P450 monooxygenase NsrP for the heterodimerization was discovered, which also accepts non-native substrates to afford novel xanthone dimers.
Original language | English |
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Journal | Organic Letters |
Volume | 20 |
Issue number | 22 |
Pages (from-to) | 7194-7200 |
Number of pages | 4 |
ISSN | 1523-7060 |
DOIs | |
Publication status | Published - 2018 |