This short communication presents a generic mathematical programming formulation for Computer-Aided Molecular Design (CAMD). A given CAMD problem, based on target properties, is formulated as a Mixed Integer Linear/Non-Linear Program (MILP/MINLP). The mathematical programming model presented here, which is formulated as an MILP/MINLP problem, considers first-order and second-order molecular groups for molecular structure representation and property estimation. It is shown that various CAMD problems can be formulated and solved through this model.
- Molecular design
- Chemical structure
- Group contribution
Zhang, L., Cignitti, S., & Gani, R. (2015). Generic Mathematical Programming Formulation and Solution for Computer-Aided Molecular Design. Computers & Chemical Engineering, 78, 79-84. https://doi.org/10.1016/j.compchemeng.2015.04.022