Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

J. Wolber; F. Ellner; B. Fridlund; A. Gram; H. Jóhannesson; G. Hansson; L.H. Hansson; Mathilde Hauge Lerche; S. Månsson; R. Servin; Morten S. Thaning; K. Golman; Jan Henrik Ardenkjær-Larsen; W. Meyer and G. Reicherz St. Goertz

doi:10.1016/j.nima.2004.03.171

Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

J. Wolber, F. Ellner, B. Fridlund, A. Gram, H. Jóhannesson, G. Hansson, L.H. Hansson, Mathilde Hauge Lerche, S. Månsson, R. Servin, Morten S. Thaning, K. Golman, Jan Henrik Ardenkjær-Larsen, W. Meyer and G. Reicherz St. Goertz

Research output: Contribution to journal › Conference article › Research › peer-review

Abstract

A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.

Original language	English
Journal	Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
Volume	526
Issue number	1-2
Pages (from-to)	173-181
ISSN	0168-9002
DOIs	https://doi.org/10.1016/j.nima.2004.03.171
Publication status	Published - 2004
Event	9th International Workshop on Polarized Solid Targets and Techniques - Bad Honnef, Germany Duration: 27 Oct 2003 → 29 Oct 2003 Conference number: 9

Conference

Conference	9th International Workshop on Polarized Solid Targets and Techniques
Number	9
Country/Territory	Germany
City	Bad Honnef
Period	27/10/2003 → 29/10/2003

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Wolber, J., Ellner, F., Fridlund, B., Gram, A., Jóhannesson, H., Hansson, G., Hansson, L. H., Lerche, M. H., Månsson, S., Servin, R., Thaning, M. S., Golman, K., Ardenkjær-Larsen, J. H., & St. Goertz, W. M. A. G. R. (2004). Generating highly polarized nuclear spins in solution using dynamic nuclear polarization. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 526(1-2), 173-181. https://doi.org/10.1016/j.nima.2004.03.171

@inproceedings{a3a6d7966db1444fa5a83a8a4fe52079,

title = "Generating highly polarized nuclear spins in solution using dynamic nuclear polarization",

abstract = "A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.",

author = "J. Wolber and F. Ellner and B. Fridlund and A. Gram and H. J{\'o}hannesson and G. Hansson and L.H. Hansson and Lerche, {Mathilde Hauge} and S. Månsson and R. Servin and Thaning, {Morten S.} and K. Golman and Ardenkj{\ae}r-Larsen, {Jan Henrik} and {St. Goertz}, {W. Meyer and G. Reicherz}",

year = "2004",

doi = "10.1016/j.nima.2004.03.171",

language = "English",

volume = "526",

pages = "173--181",

journal = "Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment",

issn = "0168-9002",

publisher = "Elsevier",

number = "1-2",

note = "9th International Workshop on Polarized Solid Targets and Techniques ; Conference date: 27-10-2003 Through 29-10-2003",

}

Wolber, J, Ellner, F, Fridlund, B, Gram, A, Jóhannesson, H, Hansson, G, Hansson, LH, Lerche, MH, Månsson, S, Servin, R, Thaning, MS, Golman, K, Ardenkjær-Larsen, JH & St. Goertz, WMAGR 2004, 'Generating highly polarized nuclear spins in solution using dynamic nuclear polarization', Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, vol. 526, no. 1-2, pp. 173-181. https://doi.org/10.1016/j.nima.2004.03.171

Generating highly polarized nuclear spins in solution using dynamic nuclear polarization. / Wolber, J.; Ellner, F.; Fridlund, B. et al.
In: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, Vol. 526, No. 1-2, 2004, p. 173-181.

Research output: Contribution to journal › Conference article › Research › peer-review

TY - GEN

T1 - Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

AU - Wolber, J.

AU - Ellner, F.

AU - Fridlund, B.

AU - Gram, A.

AU - Jóhannesson, H.

AU - Hansson, G.

AU - Hansson, L.H.

AU - Lerche, Mathilde Hauge

AU - Månsson, S.

AU - Servin, R.

AU - Thaning, Morten S.

AU - Golman, K.

AU - Ardenkjær-Larsen, Jan Henrik

AU - St. Goertz, W. Meyer and G. Reicherz

N1 - Conference code: 9

PY - 2004

Y1 - 2004

N2 - A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.

AB - A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.

U2 - 10.1016/j.nima.2004.03.171

DO - 10.1016/j.nima.2004.03.171

M3 - Conference article

SN - 0168-9002

VL - 526

SP - 173

EP - 181

JO - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

JF - Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment

IS - 1-2

T2 - 9th International Workshop on Polarized Solid Targets and Techniques

Y2 - 27 October 2003 through 29 October 2003

ER -

Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

Abstract

Conference

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