Generating highly polarized nuclear spins in solution using dynamic nuclear polarization

J. Wolber, F. Ellner, B. Fridlund, A. Gram, H. Jóhannesson, G. Hansson, L.H. Hansson, Mathilde Hauge Lerche, S. Månsson, R. Servin, Morten S. Thaning, K. Golman, Jan Henrik Ardenkjær-Larsen, W. Meyer and G. Reicherz St. Goertz

    Research output: Contribution to journalConference articleResearchpeer-review

    Abstract

    A method to generate strongly polarized nuclear spins in solution has been developed, using Dynamic Nuclear Polarization (DNP) at a temperature of 1.2K, and at a field of 3.354T, corresponding to an electron spin resonance frequency of 94GHz. Trityl radicals are used to directly polarize 13C and other low-γ nuclei. Subsequent to the DNP process, the solid sample is dissolved rapidly with a warm solvent to create a solution of molecules with highly polarized nuclear spins. Two main applications are proposed: high-resolution liquid state NMR with enhanced sensitivity, and the use of the hyperpolarized solution as an MR imaging agent.
    Original languageEnglish
    JournalNuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment
    Volume526
    Issue number1-2
    Pages (from-to)173-181
    ISSN0168-9002
    DOIs
    Publication statusPublished - 2004
    Event9th International Workshop on Polarized Solid Targets and Techniques - Bad Honnef, Germany
    Duration: 27 Oct 200329 Oct 2003
    Conference number: 9

    Conference

    Conference9th International Workshop on Polarized Solid Targets and Techniques
    Number9
    CountryGermany
    CityBad Honnef
    Period27/10/200329/10/2003

    Cite this

    Wolber, J., Ellner, F., Fridlund, B., Gram, A., Jóhannesson, H., Hansson, G., Hansson, L. H., Lerche, M. H., Månsson, S., Servin, R., Thaning, M. S., Golman, K., Ardenkjær-Larsen, J. H., & St. Goertz, W. M. A. G. R. (2004). Generating highly polarized nuclear spins in solution using dynamic nuclear polarization. Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment, 526(1-2), 173-181. https://doi.org/10.1016/j.nima.2004.03.171