Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect

Ole Lund, Ole søgaard Lund, Gregers Gram, Susanne Dam Nielsen, Kristian Schønning, Jens Ole Nielsen, John-Erik Stig Hansen, Erik Mosekilde

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Abstract

The paper presents a mathematical model of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. Our main results are that the therapy should be designed to give the transduced cells a significant but not necessarily total protection against HIV-induced cell deaths, and to avoid the production of viral mutants that are insensitive to gene therapy. The transduced cells will not survive if the gene therapy only blocks the spread of virus.
Original languageEnglish
JournalBulletin of Mathematical Biology
Volume59
Issue number4
Pages (from-to)725-745
ISSN0092-8240
Publication statusPublished - 1997

Cite this

Lund, O., Lund, O. S., Gram, G., Nielsen, S. D., Schønning, K., Nielsen, J. O., Stig Hansen, J-E., & Mosekilde, E. (1997). Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect. Bulletin of Mathematical Biology, 59(4), 725-745.