Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect

Ole Lund; Ole søgaard Lund; Gregers Gram; Susanne Dam Nielsen; Kristian Schønning; Jens Ole Nielsen; John-Erik Stig Hansen; Erik Mosekilde

Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect

Ole Lund, Ole søgaard Lund, Gregers Gram, Susanne Dam Nielsen, Kristian Schønning, Jens Ole Nielsen, John-Erik Stig Hansen, Erik Mosekilde

Department of Physics

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

The paper presents a mathematical model of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. Our main results are that the therapy should be designed to give the transduced cells a significant but not necessarily total protection against HIV-induced cell deaths, and to avoid the production of viral mutants that are insensitive to gene therapy. The transduced cells will not survive if the gene therapy only blocks the spread of virus.

Original language	English
Journal	Bulletin of Mathematical Biology
Volume	59
Issue number	4
Pages (from-to)	725-745
ISSN	0092-8240
Publication status	Published - 1997

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title = "Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect",

abstract = "The paper presents a mathematical model of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. Our main results are that the therapy should be designed to give the transduced cells a significant but not necessarily total protection against HIV-induced cell deaths, and to avoid the production of viral mutants that are insensitive to gene therapy. The transduced cells will not survive if the gene therapy only blocks the spread of virus.",

author = "Ole Lund and Lund, {Ole s{\o}gaard} and Gregers Gram and Nielsen, {Susanne Dam} and Kristian Sch{\o}nning and Nielsen, {Jens Ole} and {Stig Hansen}, John-Erik and Erik Mosekilde",

year = "1997",

language = "English",

volume = "59",

pages = "725--745",

journal = "Bulletin of Mathematical Biology",

issn = "0092-8240",

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TY - JOUR

T1 - Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect

AU - Lund, Ole

AU - Lund, Ole søgaard

AU - Gram, Gregers

AU - Nielsen, Susanne Dam

AU - Schønning, Kristian

AU - Nielsen, Jens Ole

AU - Stig Hansen, John-Erik

AU - Mosekilde, Erik

PY - 1997

Y1 - 1997

N2 - The paper presents a mathematical model of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. Our main results are that the therapy should be designed to give the transduced cells a significant but not necessarily total protection against HIV-induced cell deaths, and to avoid the production of viral mutants that are insensitive to gene therapy. The transduced cells will not survive if the gene therapy only blocks the spread of virus.

AB - The paper presents a mathematical model of the criteria for gene therapy of T helper cells to have a clinical effect on HIV infection. Our main results are that the therapy should be designed to give the transduced cells a significant but not necessarily total protection against HIV-induced cell deaths, and to avoid the production of viral mutants that are insensitive to gene therapy. The transduced cells will not survive if the gene therapy only blocks the spread of virus.

M3 - Journal article

SN - 0092-8240

VL - 59

SP - 725

EP - 745

JO - Bulletin of Mathematical Biology

JF - Bulletin of Mathematical Biology

IS - 4

ER -

Gene Therapy of T Helper Cells in HIV Infection. Mathematical Model of the Criteria for Clinical Effect

Abstract

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