Gene expression of the endolymphatic sac

Morten Friis, Tomas Martin-Bertelsen, Lennart Friis-Hansen, Ole Winther, Ricardo Henao, Mads Sølvsten Sørensen, Klaus Qvortrup

Research output: Contribution to journalJournal articleResearchpeer-review

1 Downloads (Pure)

Abstract

Conclusion: The endolymphatic sac is part of the membranous inner ear and is thought to play a role in the fluid homeostasis and immune defense of the inner ear; however, the exact function of the endolymphatic sac is not fully known. Many of the detected mRNAs in this study suggest that the endolymphatic sac has multiple and diverse functions in the inner ear. Objectives: The objective of this study was to provide a comprehensive review of the genes expressed in the endolymphatic sac in the rat and perform a functional characterization based on measured mRNA abundance. Methods:Microarray technology was used to investigate the gene expression of the endolymphatic sac with the surrounding dura. Characteristic and novel endolymphatic sac genes were determined by comparing with expressions in pure dura. Results: In all, 463 genes were identified specific for the endolymphatic sac. Functional annotation clustering revealed 29 functional clusters.
Original languageEnglish
JournalActa Oto Laryngologica
Volume131
Issue number12
Pages (from-to)1257
ISSN0001-6489
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint Dive into the research topics of 'Gene expression of the endolymphatic sac'. Together they form a unique fingerprint.

Cite this