Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

Ulla Birgitte Vogel; Mette Sørensen; Rikke Dalgaard Hansen; Anne Tjønneland; Kim Overvad; Håkan Wallin; Bjørn A. Nexø; Ole Raaschou-Nielsen

doi:10.1016/j.cankel.2006.04.001

Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

Ulla Birgitte Vogel
, Mette Sørensen
, Rikke Dalgaard Hansen
, Anne Tjønneland
, Kim Overvad
, Håkan Wallin
, Bjørn A. Nexø
, Ole Raaschou-Nielsen

Danish Cancer Society
Aarhus University Hospital
Aarhus University
National Institute of Occupational Health

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.

Original language	English
Journal	Cancer Letters
Volume	247
Issue number	1
Pages (from-to)	159-165
ISSN	0304-3835
DOIs	https://doi.org/10.1016/j.cankel.2006.04.001
Publication status	Published - 2007
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.cankel.2006.04.001

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Vogel, U. B., Sørensen, M., Hansen, R. D., Tjønneland, A., Overvad, K., Wallin, H., Nexø, B. A., & Raaschou-Nielsen, O. (2007). Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. Cancer Letters, 247(1), 159-165. https://doi.org/10.1016/j.cankel.2006.04.001

@article{056b5e53a62d4f5998824301e85d03b1,

title = "Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study",

abstract = "Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95\% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.",

author = "Vogel, \{Ulla Birgitte\} and Mette S{\o}rensen and Hansen, \{Rikke Dalgaard\} and Anne Tj{\o}nneland and Kim Overvad and H{\aa}kan Wallin and Nex{\o}, \{Bj{\o}rn A.\} and Ole Raaschou-Nielsen",

year = "2007",

doi = "10.1016/j.cankel.2006.04.001",

language = "English",

volume = "247",

pages = "159--165",

journal = "Cancer Letters",

issn = "0304-3835",

publisher = "Elsevier Ireland Ltd",

number = "1",

}

Vogel, UB, Sørensen, M, Hansen, RD, Tjønneland, A, Overvad, K, Wallin, H, Nexø, BA & Raaschou-Nielsen, O 2007, 'Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study', Cancer Letters, vol. 247, no. 1, pp. 159-165. https://doi.org/10.1016/j.cankel.2006.04.001

Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study. / Vogel, Ulla Birgitte; Sørensen, Mette; Hansen, Rikke Dalgaard et al.
In: Cancer Letters, Vol. 247, No. 1, 2007, p. 159-165.

Research output: Contribution to journal › Journal article › Research › peer-review

TY - JOUR

T1 - Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

AU - Vogel, Ulla Birgitte

AU - Sørensen, Mette

AU - Hansen, Rikke Dalgaard

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Wallin, Håkan

AU - Nexø, Bjørn A.

AU - Raaschou-Nielsen, Ole

PY - 2007

Y1 - 2007

N2 - Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.

AB - Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.

U2 - 10.1016/j.cankel.2006.04.001

DO - 10.1016/j.cankel.2006.04.001

M3 - Journal article

SN - 0304-3835

VL - 247

SP - 159

EP - 165

JO - Cancer Letters

JF - Cancer Letters

IS - 1

ER -

Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study

Abstract

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