TY - JOUR
T1 - Gene-environment interactions between smoking and a haplotype of RAI, ASE-1 and ERCC1 polymorphisms among women in relation to risk of lung cancer in a population-based study
AU - Vogel, Ulla Birgitte
AU - Sørensen, Mette
AU - Hansen, Rikke Dalgaard
AU - Tjønneland, Anne
AU - Overvad, Kim
AU - Wallin, Håkan
AU - Nexø, Bjørn A.
AU - Raaschou-Nielsen, Ole
PY - 2007
Y1 - 2007
N2 - Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
AB - Homozygous carriers of a haplotype consisting of ERCC1 Asn118Asn(A), ASE-1 G-21A(G), RAI IVS1 A4364G(A) are at increased risk of lung cancer especially among women. Here, we analyse for gene-environment interactions with the predefined haplotype in a case cohort study including 428 lung cancer cases and a comparison group of 800 persons, all from the prospective Diet, Cancer and Health cohort of 57,000 Danes. At high smoking intensity (> 20 g tobacco/day), there was only additional risk of smoking intensity among women who were homozygous carriers of the haplotype (IRR=2.03; 95% CI: 1.10-3.73 per 5 additional g tobacco/day). (c) 2006 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.cankel.2006.04.001
DO - 10.1016/j.cankel.2006.04.001
M3 - Journal article
SN - 0304-3835
VL - 247
SP - 159
EP - 165
JO - Cancer Letters
JF - Cancer Letters
IS - 1
ER -