Abstract
The futuristic human organ on a chip (HOOC) is going to replace experimental animals, but many basic functions need to be implemented to reach that goal. Today, it is possible to keep 10-13 connected organs alive for 1-3 weeks without losing a significant function in most of the organs in the system. This number of organs is sufficient to model a large part of the basic physiology of an organism. Selecting which cell models to use and how to scale these models relative to each other to best mimic an organism is still not obvious and will be the research for the next decade. However, the road to that is long and will involve engineering better hardware solutions, obtaining more knowledge about the interplay between organs and tissue, and developing better and more accessible cell models.
Original language | English |
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Title of host publication | Microfluidics and Multi Organs on Chip |
Publisher | Springer |
Publication date | 2022 |
Pages | 247-259 |
Chapter | 11 |
ISBN (Print) | 978-981-19-1378-5 |
ISBN (Electronic) | 978-981-19-1379-2 |
DOIs | |
Publication status | Published - 2022 |