Further advances in modeling transdermal uptake of SVOCs

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Abstract

To better simulate dermal uptake of SVOCs from air, we develop an enhanced transport model that includes skin surface lipids (SSL). As modeled, clothing can remove SSL by contact transfer and it can act as a source or sink for gas-phase transfer to and from SSL. Addition of SSL increases the overall resistance to uptake of SVOCs from air but also allows for more rapid release of SVOCs to sinks like clothing or clean air. We compare the model results to reported experimental uptake of di-ethyl phthalate (DEP) and di-n-butyl phthalate (DnBP), normalized by exposed skin area and the phthalate air concentration during exposure (Weschler et al., 2015). Overall, the model predicts total uptake values that are consistent with those observed in the experiments. The model predicts a normalized mass uptake of DEP of 3.1 (µg/m2)/(µg/m3) whereas the experimental results range from 1.0 to 4.3 (µg/m2)/(µg/m3). The model somewhat over-predicts uptake of DnBP: 4.6 (µg/m2)/(µg/m3) vs the experimental range of 0.49 to 3.2 (µg/m2)/(µg/m3).

Original languageEnglish
Title of host publicationProceedings of Indoor Air 2016
Number of pages2
Publication date2016
Article number268
Publication statusPublished - 2016
Event14th international conference on Indoor Air Quality and Climate - Ghent, Belgium
Duration: 3 Jul 20168 Jul 2016
Conference number: 14

Conference

Conference14th international conference on Indoor Air Quality and Climate
Number14
CountryBelgium
CityGhent
Period03/07/201608/07/2016

Keywords

  • Dermal uptake
  • Exposure model
  • Phthalates
  • Clothing
  • Skin lipids

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