Fungal cell with improved protein production capacity

Mingtao Huang (Inventor), Anastasia Krivoruchko (Inventor), Florian David (Inventor), Jens Nielsen (Inventor)

Research output: Patent

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The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.

Original languageEnglish
IPCC12P 1/ 02 A I
Patent numberWO2019027364
Filing date31/07/2017
Country/TerritoryInternational Bureau of the World Intellectual Property Organization (WIPO)
Priority date31/07/2017
Priority numberSE20170050968
Publication statusPublished - 7 Feb 2019


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