Abstract
The present invention related to the provision of genetically modified fungal cells, such as yeast cells with an improved ability for producing and secreting different recombinant proteins. The improved ability is obtained by disruption in intracellular transport between the Golgi and the endosome. In particular embodiments, the disruption is achieved by downregulation or deletion of the gene encoding a Tda3p homolog. The fungal cell and method of the invention would allow for large-scale production of recombinant proteins in fungal cells.
| Original language | English |
|---|---|
| IPC | C12P 1/ 02 A I |
| Patent number | WO2019027364 |
| Filing date | 31/07/2017 |
| Country/Territory | International Bureau of the World Intellectual Property Organization (WIPO) |
| Priority date | 31/07/2017 |
| Priority number | SE20170050968 |
| Publication status | Published - 7 Feb 2019 |