Functionalized ormosil scaffolds processed by direct laser polymerization for application in tissue engineering

A. Matei; Jørgen Schou; Stela Canulescu; M. Zamfirescu; C. Albu; B. Mitu; E. C. Buruiana; T. Buruiana; C. Mustaciosu; I. Petcu; M. Dinescu

doi:10.1016/j.apsusc.2012.10.104

Functionalized ormosil scaffolds processed by direct laser polymerization for application in tissue engineering

A. Matei, Jørgen Schou, Stela Canulescu, M. Zamfirescu, C. Albu, B. Mitu, E. C. Buruiana, T. Buruiana, C. Mustaciosu, I. Petcu, M. Dinescu

Research output: Contribution to journal › Journal article › Research › peer-review

Abstract

Synthesized N,N′-(methacryloyloxyethyl triehtoxy silyl propyl carbamoyl-oxyhexyl)-urea hybrid methacrylate was polymerized by direct laser polymerization using femtosecond laser pulses with the aim of using it for subsequent applications in tissue engineering. The as-obtained scaffolds were modified either by low pressure argon plasma treatment or by covering the structures with two different proteins (lysozyme, fibrinogen). For improved adhesion, the proteins were deposited by matrix assisted pulsed laser evaporation technique. The functionalized structures were tested in mouse fibroblasts culture and the cells morphology, proliferation, and attachment were analyzed.

Original language	English
Journal	Applied Surface Science
Volume	278
Pages (from-to)	357–361
ISSN	0169-4332
DOIs	https://doi.org/10.1016/j.apsusc.2012.10.104
Publication status	Published - 2013
Event	E-MRS 2012 Spring Meeting - Strasbourg, France Duration: 14 May 2012 → 18 May 2012

Conference

Conference	E-MRS 2012 Spring Meeting
Country/Territory	France
City	Strasbourg
Period	14/05/2012 → 18/05/2012

Keywords

Ormosil scaffolds
Direct laser writing
Low pressure plasma treatment
MAPLE

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10.1016/j.apsusc.2012.10.104

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title = "Functionalized ormosil scaffolds processed by direct laser polymerization for application in tissue engineering",

abstract = "Synthesized N,N′-(methacryloyloxyethyl triehtoxy silyl propyl carbamoyl-oxyhexyl)-urea hybrid methacrylate was polymerized by direct laser polymerization using femtosecond laser pulses with the aim of using it for subsequent applications in tissue engineering. The as-obtained scaffolds were modified either by low pressure argon plasma treatment or by covering the structures with two different proteins (lysozyme, fibrinogen). For improved adhesion, the proteins were deposited by matrix assisted pulsed laser evaporation technique. The functionalized structures were tested in mouse fibroblasts culture and the cells morphology, proliferation, and attachment were analyzed.",

keywords = "Ormosil scaffolds, Direct laser writing, Low pressure plasma treatment, MAPLE",

author = "A. Matei and J{\o}rgen Schou and Stela Canulescu and M. Zamfirescu and C. Albu and B. Mitu and Buruiana, {E. C.} and T. Buruiana and C. Mustaciosu and I. Petcu and M. Dinescu",

year = "2013",

doi = "10.1016/j.apsusc.2012.10.104",

language = "English",

volume = "278",

pages = "357–361",

journal = "Applied Surface Science",

issn = "0169-4332",

publisher = "Elsevier",

note = "E-MRS 2012 Spring Meeting ; Conference date: 14-05-2012 Through 18-05-2012",

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TY - JOUR

T1 - Functionalized ormosil scaffolds processed by direct laser polymerization for application in tissue engineering

AU - Matei, A.

AU - Schou, Jørgen

AU - Canulescu, Stela

AU - Zamfirescu, M.

AU - Albu, C.

AU - Mitu, B.

AU - Buruiana, E. C.

AU - Buruiana, T.

AU - Mustaciosu, C.

AU - Petcu, I.

AU - Dinescu, M.

PY - 2013

Y1 - 2013

N2 - Synthesized N,N′-(methacryloyloxyethyl triehtoxy silyl propyl carbamoyl-oxyhexyl)-urea hybrid methacrylate was polymerized by direct laser polymerization using femtosecond laser pulses with the aim of using it for subsequent applications in tissue engineering. The as-obtained scaffolds were modified either by low pressure argon plasma treatment or by covering the structures with two different proteins (lysozyme, fibrinogen). For improved adhesion, the proteins were deposited by matrix assisted pulsed laser evaporation technique. The functionalized structures were tested in mouse fibroblasts culture and the cells morphology, proliferation, and attachment were analyzed.

AB - Synthesized N,N′-(methacryloyloxyethyl triehtoxy silyl propyl carbamoyl-oxyhexyl)-urea hybrid methacrylate was polymerized by direct laser polymerization using femtosecond laser pulses with the aim of using it for subsequent applications in tissue engineering. The as-obtained scaffolds were modified either by low pressure argon plasma treatment or by covering the structures with two different proteins (lysozyme, fibrinogen). For improved adhesion, the proteins were deposited by matrix assisted pulsed laser evaporation technique. The functionalized structures were tested in mouse fibroblasts culture and the cells morphology, proliferation, and attachment were analyzed.

KW - Ormosil scaffolds

KW - Direct laser writing

KW - Low pressure plasma treatment

KW - MAPLE

U2 - 10.1016/j.apsusc.2012.10.104

DO - 10.1016/j.apsusc.2012.10.104

M3 - Journal article

SN - 0169-4332

VL - 278

SP - 357

EP - 361

JO - Applied Surface Science

JF - Applied Surface Science

T2 - E-MRS 2012 Spring Meeting

Y2 - 14 May 2012 through 18 May 2012

ER -

Functionalized ormosil scaffolds processed by direct laser polymerization for application in tissue engineering

Abstract

Conference

Keywords

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