Functionalization of polyvinyl alcohol composite film wrapped in am-ZnO@CuO@Au nanoparticles for antibacterial application and wound healing

Wang Wentao, Zheng Tao, Sheng Bulei, Zhou Tongchang, Zhang Qicheng, Wu Fan, Zhou Ninglin, Shen Jian, Ming Zhang, Sun Yi*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Over recent years, researchers have been intensively investigating advanced antibacterial agents. However, the drug resistance in bacteria remains to be a challenging problem for wound healing. Therefore, it is urgent to find a novel effective antibacterial therapy to enhance wound healing. Herein, we reported a new antibacterial film (PVA@am-ZnO@CuO@Au) which showed heat, reactive oxygen species (ROS), Zn2+, and Cu2+-induced disinfection. An antibacterial efficacy of 98.7% against Escherichia coli and 97.5% against Staphylococcus aureus was obtained by PVA@am-ZnO@CuO@Au film under red laser irradiation for 10 min, with the combined effect of photothermal, photodynamic, and released Zn2+ and Cu2+. In vivo wound healing and tissue compatibility studies were carried out over a period of 10 days on skin wounds. Fast healing was observed in PVA@am-ZnO@CuO@Au film treated wounds with minimum scarring. PVA@am-ZnO@CuO@Au film also possessed sustained antibacterial properties due to the large embedded depth of am-ZnO@CuO@Au NPs. The technique and resulting materials have large potential for applications in would healing.
Original languageEnglish
JournalApplied Materials Today
Volume17
Pages (from-to)36-44
ISSN2352-9407
DOIs
Publication statusPublished - 2019

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