Over recent years, researchers have been intensively investigating advanced antibacterial agents. However, the drug resistance in bacteria remains to be a challenging problem for wound healing. Therefore, it is urgent to find a novel effective antibacterial therapy to enhance wound healing. Herein, we reported a new antibacterial film (PVA@am-ZnO@CuO@Au) which showed heat, reactive oxygen species (ROS), Zn2+, and Cu2+-induced disinfection. An antibacterial efficacy of 98.7% against Escherichia coli and 97.5% against Staphylococcus aureus was obtained by PVA@am-ZnO@CuO@Au film under red laser irradiation for 10 min, with the combined effect of photothermal, photodynamic, and released Zn2+ and Cu2+. In vivo wound healing and tissue compatibility studies were carried out over a period of 10 days on skin wounds. Fast healing was observed in PVA@am-ZnO@CuO@Au film treated wounds with minimum scarring. PVA@am-ZnO@CuO@Au film also possessed sustained antibacterial properties due to the large embedded depth of am-ZnO@CuO@Au NPs. The technique and resulting materials have large potential for applications in would healing.
Wentao, W., Tao, Z., Bulei, S., Tongchang, Z., Qicheng, Z., Fan, W., Ninglin, Z., Jian, S., Zhang, M., & Yi, S. (2019). Functionalization of polyvinyl alcohol composite film wrapped in am-ZnO@CuO@Au nanoparticles for antibacterial application and wound healing. Applied Materials Today, 17, 36-44. https://doi.org/10.1016/j.apmt.2019.07.001