Functional strain analysis of the gut microbiota in individuals with IgA deficiency

Janne Marie Moll, Pernille Neve Myers, Chenchen Zhang, Carsten Eriksen, Hui Zhao, Qiang Pan-Hammarström, Kaiye Cai, Huijue Jia, Henrik Bjørn Nielsen, Karsten Kristiansen, Susanne Brix Pedersen, Lennart Hammarström

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

Abstract

Immunoglobulin A (IgA) is the main immunoglobulin secreted at mucosal surfaces where it binds microbial antigens in the gut lumen. Despite being ubiquitous at mucosal surfaces, IgA deficiency (IgAD) is mostly asymptomatic or result only in mild clinical manifestations. Here we used a novel species-based functionality approach to investigate the role of IgA in the gut. We show that individuals with IgAD are enriched for species which have an increased inflammatory potential as compared to their household controls. Further we used strain-level analysis to show that the increased level of pathogenic potential is not due to strain selection, suggesting that IgA exerts its function by keeping potentially invading bacteria at bay.
Original languageEnglish
Publication date2019
Number of pages1
Publication statusPublished - 2019
EventAnnual Meeting ’Immunology and Infectious Diseases’ - Konvertum konferencecenter, Helsingør, Denmark
Duration: 28 Aug 201930 Aug 2019

Conference

ConferenceAnnual Meeting ’Immunology and Infectious Diseases’
LocationKonvertum konferencecenter
CountryDenmark
CityHelsingør
Period28/08/201930/08/2019

Cite this

Moll, J. M., Myers, P. N., Zhang, C., Eriksen, C., Zhao, H., Pan-Hammarström, Q., ... Hammarström, L. (2019). Functional strain analysis of the gut microbiota in individuals with IgA deficiency. Abstract from Annual Meeting ’Immunology and Infectious Diseases’, Helsingør, Denmark.
Moll, Janne Marie ; Myers, Pernille Neve ; Zhang, Chenchen ; Eriksen, Carsten ; Zhao, Hui ; Pan-Hammarström, Qiang ; Cai, Kaiye ; Jia, Huijue ; Nielsen, Henrik Bjørn ; Kristiansen, Karsten ; Pedersen, Susanne Brix ; Hammarström, Lennart. / Functional strain analysis of the gut microbiota in individuals with IgA deficiency. Abstract from Annual Meeting ’Immunology and Infectious Diseases’, Helsingør, Denmark.1 p.
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title = "Functional strain analysis of the gut microbiota in individuals with IgA deficiency",
abstract = "Immunoglobulin A (IgA) is the main immunoglobulin secreted at mucosal surfaces where it binds microbial antigens in the gut lumen. Despite being ubiquitous at mucosal surfaces, IgA deficiency (IgAD) is mostly asymptomatic or result only in mild clinical manifestations. Here we used a novel species-based functionality approach to investigate the role of IgA in the gut. We show that individuals with IgAD are enriched for species which have an increased inflammatory potential as compared to their household controls. Further we used strain-level analysis to show that the increased level of pathogenic potential is not due to strain selection, suggesting that IgA exerts its function by keeping potentially invading bacteria at bay.",
author = "Moll, {Janne Marie} and Myers, {Pernille Neve} and Chenchen Zhang and Carsten Eriksen and Hui Zhao and Qiang Pan-Hammarstr{\"o}m and Kaiye Cai and Huijue Jia and Nielsen, {Henrik Bj{\o}rn} and Karsten Kristiansen and Pedersen, {Susanne Brix} and Lennart Hammarstr{\"o}m",
year = "2019",
language = "English",
note = "Annual Meeting ’Immunology and Infectious Diseases’ ; Conference date: 28-08-2019 Through 30-08-2019",

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Moll, JM, Myers, PN, Zhang, C, Eriksen, C, Zhao, H, Pan-Hammarström, Q, Cai, K, Jia, H, Nielsen, HB, Kristiansen, K, Pedersen, SB & Hammarström, L 2019, 'Functional strain analysis of the gut microbiota in individuals with IgA deficiency', Annual Meeting ’Immunology and Infectious Diseases’, Helsingør, Denmark, 28/08/2019 - 30/08/2019.

Functional strain analysis of the gut microbiota in individuals with IgA deficiency. / Moll, Janne Marie; Myers, Pernille Neve; Zhang, Chenchen; Eriksen, Carsten; Zhao, Hui; Pan-Hammarström, Qiang; Cai, Kaiye; Jia, Huijue; Nielsen, Henrik Bjørn; Kristiansen, Karsten; Pedersen, Susanne Brix; Hammarström, Lennart.

2019. Abstract from Annual Meeting ’Immunology and Infectious Diseases’, Helsingør, Denmark.

Research output: Contribution to conferenceConference abstract for conferenceResearchpeer-review

TY - ABST

T1 - Functional strain analysis of the gut microbiota in individuals with IgA deficiency

AU - Moll, Janne Marie

AU - Myers, Pernille Neve

AU - Zhang, Chenchen

AU - Eriksen, Carsten

AU - Zhao, Hui

AU - Pan-Hammarström, Qiang

AU - Cai, Kaiye

AU - Jia, Huijue

AU - Nielsen, Henrik Bjørn

AU - Kristiansen, Karsten

AU - Pedersen, Susanne Brix

AU - Hammarström, Lennart

PY - 2019

Y1 - 2019

N2 - Immunoglobulin A (IgA) is the main immunoglobulin secreted at mucosal surfaces where it binds microbial antigens in the gut lumen. Despite being ubiquitous at mucosal surfaces, IgA deficiency (IgAD) is mostly asymptomatic or result only in mild clinical manifestations. Here we used a novel species-based functionality approach to investigate the role of IgA in the gut. We show that individuals with IgAD are enriched for species which have an increased inflammatory potential as compared to their household controls. Further we used strain-level analysis to show that the increased level of pathogenic potential is not due to strain selection, suggesting that IgA exerts its function by keeping potentially invading bacteria at bay.

AB - Immunoglobulin A (IgA) is the main immunoglobulin secreted at mucosal surfaces where it binds microbial antigens in the gut lumen. Despite being ubiquitous at mucosal surfaces, IgA deficiency (IgAD) is mostly asymptomatic or result only in mild clinical manifestations. Here we used a novel species-based functionality approach to investigate the role of IgA in the gut. We show that individuals with IgAD are enriched for species which have an increased inflammatory potential as compared to their household controls. Further we used strain-level analysis to show that the increased level of pathogenic potential is not due to strain selection, suggesting that IgA exerts its function by keeping potentially invading bacteria at bay.

M3 - Conference abstract for conference

ER -

Moll JM, Myers PN, Zhang C, Eriksen C, Zhao H, Pan-Hammarström Q et al. Functional strain analysis of the gut microbiota in individuals with IgA deficiency. 2019. Abstract from Annual Meeting ’Immunology and Infectious Diseases’, Helsingør, Denmark.