Functional strain analysis of the gut microbiota in individuals with IgA deficiency

Janne Marie Moll, Pernille Neve Myers, Chenchen Zhang, Carsten Eriksen, Hui Zhao, Qiang Pan-Hammarström, Kaiye Cai, Huijue Jia, Henrik Bjørn Nielsen, Karsten Kristiansen, Susanne Brix Pedersen, Lennart Hammarström

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Abstract

Immunoglobulin A (IgA) is the main immunoglobulin secreted at mucosal surfaces where it binds microbial antigens in the gut lumen. Despite being ubiquitous at mucosal surfaces, IgA deficiency (IgAD) is mostly asymptomatic or result only in mild clinical manifestations. Here we used a novel species-based functionality approach to investigate the role of IgA in the gut. We show that individuals with IgAD are enriched for species which have an increased inflammatory potential as compared to their household controls. Further we used strain-level analysis to show that the increased level of pathogenic potential is not due to strain selection, suggesting that IgA exerts its function by keeping potentially invading bacteria at bay.
Original languageEnglish
Publication date2019
Number of pages1
Publication statusPublished - 2019
EventAnnual Meeting ’Immunology and Infectious Diseases’ - Konvertum konferencecenter, Helsingør, Denmark
Duration: 28 Aug 201930 Aug 2019

Conference

ConferenceAnnual Meeting ’Immunology and Infectious Diseases’
LocationKonvertum konferencecenter
Country/TerritoryDenmark
CityHelsingør
Period28/08/201930/08/2019

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