Functional modeling of neural-glial interaction

D.E. Postnov, L.S. Ryazanova, Olga Sosnovtseva

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

We propose a generalized mathematical model for a small neural-glial ensemble. The model incorporates subunits of the tripartite synapse that includes a presynaptic neuron, the synaptic terminal itself, a postsynaptic neuron, and a glial cell. The glial cell is assumed to be activated via two different pathways: (i) the fast increase of intercellular [K+] produced by the spiking activity of the postsynaptic neuron, and (ii) the slow production of a mediator triggered by the synaptic activity. Our model predicts the long-term potentiation of the postsynaptic neuron as well as various [Ca2+] transients in response to the activation of different pathways.
Original languageEnglish
JournalBiosystems
Volume89
Issue number1-3
Pages (from-to)84-91
ISSN0303-2647
DOIs
Publication statusPublished - 2007

Keywords

  • functional modeling
  • glion
  • neural-glial interaction

Fingerprint Dive into the research topics of 'Functional modeling of neural-glial interaction'. Together they form a unique fingerprint.

Cite this