Functional demonstration of adaptive immunity in zebrafish using DNA vaccination.

Niels Lorenzen, Ellen Lorenzen, Katja Einer-Jensen, Jesper Skou Rasmussen, Torben Egil Kjær, Thomas Vesely

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    Due to the well characterized genome, overall highly synteny with the human genome and its suitability for functional genomics studies, the zebrafish is considered to be an ideal animal model for basic studies of mechanisms of diseases and immunity in vertebrates including humans. While several studies have documented existence of a classical innate immune response, there is mainly indirect evidence of functional adaptive immunity. To address this aspect, groups of zebrafish were vaccinated with DNA-vaccines against the rhabdoviruses VHSV, IHNV and SVCV. Seven weeks later, the fish were challenged with SVCV by immersion. Despite some variability between replicate aquaria, there was a protective effect of the homologous vaccine and no effect of the heterologous vaccines. The results therefore confirm the existence of not only a well developed but also a fully functional adaptive immune system in zebrafish.
    Original languageEnglish
    Publication date2009
    Publication statusPublished - 2009
    EventScofda and Dafinet Symposium 2009
    - University of Copenhagen, Copenhagen, Denmark
    Duration: 4 Nov 20095 Nov 2009


    ConferenceScofda and Dafinet Symposium 2009
    LocationUniversity of Copenhagen
    OtherSustainable Control of Fish Dseases in Aquaculture & Danish Fish Immunology Research Network : Research School Scofda and DaFiNet


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