Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein

J. P. Langeveld, Søren Kamstrup, Åse Uttenthal, Bertel Strandbygaard, C Vela, K Dalsgaard, N. J. Beekman, R. H. Meloen, J. I. Casal

    Research output: Contribution to journalJournal articleResearch

    Abstract

    Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.
    Original languageEnglish
    JournalVaccine
    Volume13
    Issue number11
    Pages (from-to)1033-1037
    ISSN0264-410X
    DOIs
    Publication statusPublished - 1995

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