Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein

J. P. Langeveld; Søren Kamstrup; Åse Uttenthal; Bertel Strandbygaard; C Vela; K Dalsgaard; N. J. Beekman; R. H. Meloen; J. I. Casal

doi:10.1016/0264-410X(95)00021-R

Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein

J. P. Langeveld, Søren Kamstrup, Åse Uttenthal, Bertel Strandbygaard, C Vela, K Dalsgaard, N. J. Beekman, R. H. Meloen, J. I. Casal

Research output: Contribution to journal › Journal article › Research

Abstract

Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.

Original language	English
Journal	Vaccine
Volume	13
Issue number	11
Pages (from-to)	1033-1037
ISSN	0264-410X
DOIs	https://doi.org/10.1016/0264-410X(95)00021-R
Publication status	Published - 1995

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title = "Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein",

abstract = "Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.",

author = "Langeveld, {J. P.} and S{\o}ren Kamstrup and {\AA}se Uttenthal and Bertel Strandbygaard and C Vela and K Dalsgaard and Beekman, {N. J.} and Meloen, {R. H.} and Casal, {J. I.}",

year = "1995",

doi = "10.1016/0264-410X(95)00021-R",

language = "English",

volume = "13",

pages = "1033--1037",

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TY - JOUR

T1 - Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein

AU - Langeveld, J. P.

AU - Kamstrup, Søren

AU - Uttenthal, Åse

AU - Strandbygaard, Bertel

AU - Vela, C

AU - Dalsgaard, K

AU - Beekman, N. J.

AU - Meloen, R. H.

AU - Casal, J. I.

PY - 1995

Y1 - 1995

N2 - Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.

AB - Two recently developed vaccines—one based on synthetic peptide and one based on recombinant capsid protein—fully protected dogs against heavy experimental canine parvovirus (CPV) infection. The high sequence homology (>98%) and antigenic similarity between CPV and mink enteritis virus (MEV), feline panleukopenia virus, and raccoon parvovirus, suggest that both vaccines could protect mink, cats and raccoons against these respective host range variants. This was tested in mink and turned out to be the case. The two vaccines were fully protective and as effective as a conventional commercial vaccine based on inactivated virus. Surprisingly, this protection was obtained after only a single injection. Furthermore, the vaccinal dose of 150 μg of conjugated peptide or 3 μg of recombinant VP2 particles per animal, are sufficiently low to be cost-effective and applicable on a large scale.

U2 - 10.1016/0264-410X(95)00021-R

DO - 10.1016/0264-410X(95)00021-R

M3 - Journal article

SN - 0264-410X

VL - 13

SP - 1033

EP - 1037

JO - Vaccine

JF - Vaccine

IS - 11

ER -

Full protection in mink against mink enteritis virus with new generation canine parvovirus vaccines based on synthetic peptide or recombinant protein

Abstract

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