Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study

Francesca L. Crowe, Andrew W. Roddam, Timothy J. Key, Paul N. Appleby, Kim Overvad, Marianne Uhre Jakobsen, Anne Tjonneland, Louise Hansen, Heiner Boeing, Cornelia Weikert, Jakob Linseisen, Rudolf Kaaks, Antonia Trichopoulou, Gesthimani Misirli, Pagona Lagiou, Carlotta Sacerdote, Valeria Pala, Domenico Palli, Rosario Tumino, Salvatore PanicoH. Bas Bueno-de-Mesquita, Jolanda Boer, Carla H. van Gils, Joline W. J. Beulens, Aurelio Barricarte, Laudina Rodriguez, Nerea Larranaga, Maria-Jose Sanchez, Maria-Jose Tormo, Genevieve Buckland, Eiliv Lund, Bo Hedblad, Olle Melander, Jan-Hakan Jansson, Patrik Wennberg, Nicholas J. Wareham, Nadia Slimani, Isabelle Romieu, Mazda Jenab, John Danesh, Valentina Gallo, Teresa Norat, Elio Riboli, Prospective Invest Canc N European

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Aims A higher intake of fruits and vegetables has been associated with a lower risk of ischaemic heart disease (IHD), but there is some uncertainty about the interpretation of this association. The objective was to assess the relation between fruit and vegetable intake and risk of mortality from IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study.Methods and results After an average of 8.4 years of follow-up, there were 1636 deaths from IHD among 313 074 men and women without previous myocardial infarction or stroke from eight European countries. Participants consuming at least eight portions (80 g each) of fruits and vegetables a day had a 22% lower risk of fatal IHD [relative risk (RR) = 0.78, 95% confidence interval (CI): 0.65-0.95] compared with those consuming fewer than three portions a day. After calibration of fruit and vegetable intake to account for differences in dietary assessment between the participating centres, a one portion (80 g) increment in fruit and vegetable intake was associated with a 4% lower risk of fatal IHD (RR = 0.96, 95% CI: 0.92-1.00, P for trend = 0.033).Conclusion Results from this large observational study suggest that a higher intake of fruits and vegetables is associated with a reduced risk of IHD mortality. Whether this association is causal and, if so, the biological mechanism(s) by which fruits and vegetables operate to lower IHD risks remains unclear.
Original languageEnglish
JournalEuropean Heart Journal
Volume32
Issue number10
Pages (from-to)1235-1243
Number of pages9
ISSN0195-668X
DOIs
Publication statusPublished - 2011
Externally publishedYes

Keywords

  • Frutis
  • Coronary disease
  • Prospective cohort studies
  • Vegetables

Cite this

Crowe, F. L., Roddam, A. W., Key, T. J., Appleby, P. N., Overvad, K., Jakobsen, M. U., Tjonneland, A., Hansen, L., Boeing, H., Weikert, C., Linseisen, J., Kaaks, R., Trichopoulou, A., Misirli, G., Lagiou, P., Sacerdote, C., Pala, V., Palli, D., Tumino, R., ... European, P. I. C. N. (2011). Fruit and vegetable intake and mortality from ischaemic heart disease: results from the European Prospective Investigation into Cancer and Nutrition (EPIC)-Heart study. European Heart Journal, 32(10), 1235-1243. https://doi.org/10.1093/eurheartj/ehq465