When doing a challenging puzzle, having colored pieces can make it significantly easier to solve compared to non‐colored pieces. Similarly, the use of augmented fragment libraries for fragment‐based drug discovery (FBDD) may significantly aid the development of a new drug compared to the use of standard fragment libraries. Such library strategies include the application of specialized fragments for NMR spectroscopy and X‐ray crystallography, covalent linkage for mass spectrometry, dynamic combinatorial chemistry, and optimized fragments. These approaches may accelerate drug discovery either by improving the speed or quality of fragment‐based screening or by enabling faster hit‐to‐lead chemistry for fragment elaboration. For more details see the Minireview by N. S. Troelsen and M. H. Clausen on page 11391 ff.