From second generation feed-stocks to innovative fermentation and downstream techniques for succinic acid production

Enrico Mancini, Seyed Soheil Mansouri, Krist V. Gernaey, Jianquan Luo, Manuel Pinelo*

*Corresponding author for this work

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

Succinic acid (SA) is one of the most important biobuilding blocks in biorefinery. Its production from fermentation of renewable biomass sources is becoming a consolidated alternative that is more sustainable and potentially more economic than the traditional petroleum-based path for SA production. Fermentative production of SA has been successfully commercialized and a large and increasing number of SA-derivatives are promoting the economic stability of this production. However, the companies producing SA from fermentation are targeting specialized markets and the production is far from large-scale bulk chemical synthesis. In order to develop optimized and economic processes, the best candidates in every step of the SA production process must be identified. In this paper, the most promising biomass sources, pretreatment methods, fermentation conditions (i.e. host microorganism, fermenter design and operative mode) and separation techniques for industrial SA production are critically reviewed. Selection of the host microorganism is a key factor for SA production. However, the availability, potential and sustainability of feedstocks, fermentation and separation process must also be carefully evaluated for a cost-effective and environmentally sustainable SA production.
Original languageEnglish
JournalCritical Reviews in Environmental Science and Technology
ISSN1064-3389
DOIs
Publication statusAccepted/In press - 2019

Keywords

  • Biomass pretreatment
  • Membranes for downstream processing
  • Second generation biomass

Cite this

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title = "From second generation feed-stocks to innovative fermentation and downstream techniques for succinic acid production",
abstract = "Succinic acid (SA) is one of the most important biobuilding blocks in biorefinery. Its production from fermentation of renewable biomass sources is becoming a consolidated alternative that is more sustainable and potentially more economic than the traditional petroleum-based path for SA production. Fermentative production of SA has been successfully commercialized and a large and increasing number of SA-derivatives are promoting the economic stability of this production. However, the companies producing SA from fermentation are targeting specialized markets and the production is far from large-scale bulk chemical synthesis. In order to develop optimized and economic processes, the best candidates in every step of the SA production process must be identified. In this paper, the most promising biomass sources, pretreatment methods, fermentation conditions (i.e. host microorganism, fermenter design and operative mode) and separation techniques for industrial SA production are critically reviewed. Selection of the host microorganism is a key factor for SA production. However, the availability, potential and sustainability of feedstocks, fermentation and separation process must also be carefully evaluated for a cost-effective and environmentally sustainable SA production.",
keywords = "Biomass pretreatment, Membranes for downstream processing, Second generation biomass",
author = "Enrico Mancini and Mansouri, {Seyed Soheil} and Gernaey, {Krist V.} and Jianquan Luo and Manuel Pinelo",
year = "2019",
doi = "10.1080/10643389.2019.1670530",
language = "English",
journal = "Critical Reviews in Environmental Science & Technology",
issn = "1064-3389",
publisher = "Taylor & Francis Inc.",

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TY - JOUR

T1 - From second generation feed-stocks to innovative fermentation and downstream techniques for succinic acid production

AU - Mancini, Enrico

AU - Mansouri, Seyed Soheil

AU - Gernaey, Krist V.

AU - Luo, Jianquan

AU - Pinelo, Manuel

PY - 2019

Y1 - 2019

N2 - Succinic acid (SA) is one of the most important biobuilding blocks in biorefinery. Its production from fermentation of renewable biomass sources is becoming a consolidated alternative that is more sustainable and potentially more economic than the traditional petroleum-based path for SA production. Fermentative production of SA has been successfully commercialized and a large and increasing number of SA-derivatives are promoting the economic stability of this production. However, the companies producing SA from fermentation are targeting specialized markets and the production is far from large-scale bulk chemical synthesis. In order to develop optimized and economic processes, the best candidates in every step of the SA production process must be identified. In this paper, the most promising biomass sources, pretreatment methods, fermentation conditions (i.e. host microorganism, fermenter design and operative mode) and separation techniques for industrial SA production are critically reviewed. Selection of the host microorganism is a key factor for SA production. However, the availability, potential and sustainability of feedstocks, fermentation and separation process must also be carefully evaluated for a cost-effective and environmentally sustainable SA production.

AB - Succinic acid (SA) is one of the most important biobuilding blocks in biorefinery. Its production from fermentation of renewable biomass sources is becoming a consolidated alternative that is more sustainable and potentially more economic than the traditional petroleum-based path for SA production. Fermentative production of SA has been successfully commercialized and a large and increasing number of SA-derivatives are promoting the economic stability of this production. However, the companies producing SA from fermentation are targeting specialized markets and the production is far from large-scale bulk chemical synthesis. In order to develop optimized and economic processes, the best candidates in every step of the SA production process must be identified. In this paper, the most promising biomass sources, pretreatment methods, fermentation conditions (i.e. host microorganism, fermenter design and operative mode) and separation techniques for industrial SA production are critically reviewed. Selection of the host microorganism is a key factor for SA production. However, the availability, potential and sustainability of feedstocks, fermentation and separation process must also be carefully evaluated for a cost-effective and environmentally sustainable SA production.

KW - Biomass pretreatment

KW - Membranes for downstream processing

KW - Second generation biomass

U2 - 10.1080/10643389.2019.1670530

DO - 10.1080/10643389.2019.1670530

M3 - Journal article

JO - Critical Reviews in Environmental Science & Technology

JF - Critical Reviews in Environmental Science & Technology

SN - 1064-3389

ER -