From genomes to in silico cells via metabolic networks

Research output: Contribution to journalJournal article – Annual report year: 2005Researchpeer-review

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From genomes to in silico cells via metabolic networks. / Borodina, Irina; Nielsen, Jens.

In: Current Opinion in Biotechnology, Vol. 16, No. 3, 2005, p. 350-355.

Research output: Contribution to journalJournal article – Annual report year: 2005Researchpeer-review

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@article{9191950b4f7e4e4dbd4d2950c92ac5fe,
title = "From genomes to in silico cells via metabolic networks",
abstract = "Genome-scale metabolic models are the focal point of systems biology as they allow the collection of various data types in a form suitable for mathematical analysis. High-quality metabolic networks and metabolic networks with incorporated regulation have been successfully used for the analysis of phenotypes from phenotypic arrays and in gene-deletion studies. They have also been used for gene expression analysis guided by metabolic network structure, leading to the identification of commonly regulated genes. Thus, genome-scale metabolic modeling currently stands out as one of the most promising approaches to obtain an in silico prediction of cellular function based on the interaction of all of the cellular components.",
author = "Irina Borodina and Jens Nielsen",
year = "2005",
doi = "10.1016/j.copbio.2005.04.008",
language = "English",
volume = "16",
pages = "350--355",
journal = "Current Opinion in Biotechnology",
issn = "0958-1669",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "3",

}

RIS

TY - JOUR

T1 - From genomes to in silico cells via metabolic networks

AU - Borodina, Irina

AU - Nielsen, Jens

PY - 2005

Y1 - 2005

N2 - Genome-scale metabolic models are the focal point of systems biology as they allow the collection of various data types in a form suitable for mathematical analysis. High-quality metabolic networks and metabolic networks with incorporated regulation have been successfully used for the analysis of phenotypes from phenotypic arrays and in gene-deletion studies. They have also been used for gene expression analysis guided by metabolic network structure, leading to the identification of commonly regulated genes. Thus, genome-scale metabolic modeling currently stands out as one of the most promising approaches to obtain an in silico prediction of cellular function based on the interaction of all of the cellular components.

AB - Genome-scale metabolic models are the focal point of systems biology as they allow the collection of various data types in a form suitable for mathematical analysis. High-quality metabolic networks and metabolic networks with incorporated regulation have been successfully used for the analysis of phenotypes from phenotypic arrays and in gene-deletion studies. They have also been used for gene expression analysis guided by metabolic network structure, leading to the identification of commonly regulated genes. Thus, genome-scale metabolic modeling currently stands out as one of the most promising approaches to obtain an in silico prediction of cellular function based on the interaction of all of the cellular components.

U2 - 10.1016/j.copbio.2005.04.008

DO - 10.1016/j.copbio.2005.04.008

M3 - Journal article

VL - 16

SP - 350

EP - 355

JO - Current Opinion in Biotechnology

JF - Current Opinion in Biotechnology

SN - 0958-1669

IS - 3

ER -