From Fed-batch to Continuous Enzymatic Biodiesel Production

Jason Anthony Price, Mathias Nordblad, John M. Woodley, Jakob K. Huusom

Research output: Chapter in Book/Report/Conference proceedingArticle in proceedingsResearchpeer-review

1 Downloads (Pure)


In this this paper, we use mechanistic modelling to guide the development of acontinuous enzymatic process that is performed as a fed-batch operation. In this workwe use the enzymatic biodiesel process as a case study. A mechanistic model developedin our previous work was used to determine the reactor operating conditions for adesired conversion. However, in using a detailed mechanistic model, given the largenumber of parameters and few experimental data points, the parameters were found notidentifiable. The model is then only applicable within the limited operating range for which the model was validated. We hypothesize that fitting this model to fed-batch and continuous stirred tank reactor (CSTR) data together will enable us to use the model for determination of residence times to reach a specified conversion in a CSTR. With this approach, the model fits the experimental data for the five measured components (triglycerides, diglycerides, monoglycerides, free fatty acid and fatty acid methyl esters(biodiesel)) much better than using fed-batch data alone given the smaller residuals. We also observe a reduction in the correlation between the parameters.The model was then used to predict that 5 reactors are required (with a combined residence time of 30 hours) to reach a final biodiesel concentration within 2 % of the95.6 mass % achieved in a fed-batch operation, for 24 hours.
Original languageEnglish
Title of host publicationProceedings of the 25th European Symposium on Computer Aided Process Engineering
EditorsKrist V. Gernaey, Jakob K. Huusom, Rafiqul Gani
Publication date2015
Publication statusPublished - 2015
Event25th European Symposium on Computer Aided Process Engineering : 12th International Symposium on Process Systems Engineering - Copenhagen, Denmark
Duration: 31 May 20154 Jun 2015


Conference25th European Symposium on Computer Aided Process Engineering
Internet address
SeriesComputer Aided Chemical Engineering


  • Process modelling
  • Parameter estimation
  • Enzymatic Biodiesel


Dive into the research topics of 'From Fed-batch to Continuous Enzymatic Biodiesel Production'. Together they form a unique fingerprint.

Cite this