From Cell Death to Metabolism: Holin-Antiholin Homologues with New Functions

Marielle H. van den Esker, Ákos T. Kovács, Oscar P. Kuipers

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Abstract

Programmed cell death in bacteria is generally triggered by membrane proteins with functions analogous to those of bacteriophage holins: they disrupt the membrane potential, whereas antiholins antagonize this process. The holin-like class of proteins is present in all three domains of life, but their functions can be different, depending on the species. Using a series of biochemical and genetic approaches, in a recent article in mBio, Charbonnier et al. (mBio 8:e00976-17, 2017, https://doi.org/10.1128/mBio.00976-17) demonstrate that the antiholin homologue in Bacillus subtilis transports pyruvate and is regulated in an unconventional way by its substrate molecule. Here, we discuss the connection between cell death and metabolism in various bacteria carrying genes encoding these holin-antiholin analogues and place the recent study by Charbonnier et al. in an evolutionary context.
Original languageEnglish
Article numbere01963-17
JournalmBio (Online)
Volume8
Issue number6
Number of pages5
ISSN2150-7511
DOIs
Publication statusPublished - 2017

Bibliographical note

All Free via Open Access: OA

Keywords

  • Bacillus subtilis
  • Staphylococcus aureus
  • Antiholin
  • Evolution
  • Holin
  • Metabolism
  • Programmed cell death
  • Pyruvate

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