Frequency encoding in renal blood flow regulation

D.J. Marsh, Olga Sosnovtseva, A.N. Pavlov, K.P. Yip, N.H. Hostein-Rathlou

Research output: Contribution to journalJournal articleResearchpeer-review

Abstract

With a model of renal blood flow regulation, we examined consequences of tubuloglomerular feedback (TGF) coupling to the myogenic mechanism via voltage-gated Ca channels. The model reproduces the characteristic oscillations of the two mechanisms and predicts frequency and amplitude modulation of the myogenic oscillation by TGF. Analysis by wavelet transforms of single-nephron blood flow confirms that both amplitude and frequency of the myogenic oscillation are modulated by TGF. We developed a double-wavelet transform technique to estimate modulation frequency. Median value of the ratio of modulation frequency to TGF frequency in measurements from 10 rats was 0.95 for amplitude modulation and 0.97 for frequency modulation, a result consistent with TGF as the modulating signal. The simulation predicted that the modulation was regular, while the experimental data showed much greater variability from one TGF cycle to the next. We used a blood pressure signal recorded by telemetry from a conscious rat as the input to the model. Blood pressure fluctuations induced variability in the modulation records similar to those found in the nephron blood flow results. Frequency and amplitude modulation can provide robust communication between TGF and the myogenic mechanism.
Original languageEnglish
JournalAmerican Journal of Physiology-Regulatory Integrative and Comparative Physiology
Volume288
Issue number5
Pages (from-to)R1160-R1167
ISSN0363-6119
Publication statusPublished - 2005

Keywords

  • myogenic mechanism
  • nonlinear interactions
  • tubuloglomerular feedback
  • amplitude modulation

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